Non-homologous DNA end joining in anticancer therapy
E Pastwa, M Malinowski - Current cancer drug targets, 2007 - benthamdirect.com
Non-homologous DNA end joining (NHEJ) is the major pathway for the repair of double-
strand breaks (DSBs) in human cells. Proteins involved in NHEJ pathway can become …
strand breaks (DSBs) in human cells. Proteins involved in NHEJ pathway can become …
DNA double-strand repair by nonhomologous end joining and its clinical relevance
Emerging evidence indicates that nonhomologous end joining (NHEJ) is comprised
primarily of canonical NHEJ and alternative NHEJ (or noncanonical NHEJ) pathways. The …
primarily of canonical NHEJ and alternative NHEJ (or noncanonical NHEJ) pathways. The …
The PI3K/mTOR inhibitor ompalisib suppresses nonhomologous end joining and sensitizes cancer cells to radio-and chemotherapy
J Du, F Chen, J Yu, L Jiang, M Zhou - Molecular Cancer Research, 2021 - AACR
As the predominant pathway for the repair of DNA double-strand breaks (DSB), non-
homologous end joining (NHEJ) attenuates the efficacy of cancer treatment which relies on …
homologous end joining (NHEJ) attenuates the efficacy of cancer treatment which relies on …
In vitro non-homologous DNA end joining assays—the 20th anniversary
E Pastwa, RI Somiari, M Malinowski, SB Somiari… - The international journal …, 2009 - Elsevier
DNA double-strand breaks (DSBs) are the most serious forms of DNA damage in cells.
Unrepaired or misrepaired DSBs account for some of the genetic instabilities that lead to …
Unrepaired or misrepaired DSBs account for some of the genetic instabilities that lead to …
[HTML][HTML] DNA double strand break repair via non-homologous end-joining
AJ Davis, DJ Chen - Translational cancer research, 2013 - ncbi.nlm.nih.gov
DNA double-stranded breaks (DSB) are among the most dangerous forms of DNA damage.
Unrepaired DSBs results in cells undergoing apoptosis or senescence whereas mis …
Unrepaired DSBs results in cells undergoing apoptosis or senescence whereas mis …
SCR7, an inhibitor of NHEJ can sensitize tumor cells to ionization radiation
Nonhomologous end joining (NHEJ), one of the major DNA double‐strand break repair
pathways, plays a significant role in cancer cell proliferation and resistance to radio and …
pathways, plays a significant role in cancer cell proliferation and resistance to radio and …
The role of the core non-homologous end joining factors in carcinogenesis and cancer
DNA double-strand breaks (DSBs) are deleterious DNA lesions that if left unrepaired or are
misrepaired, potentially result in chromosomal aberrations, known drivers of carcinogenesis …
misrepaired, potentially result in chromosomal aberrations, known drivers of carcinogenesis …
Marked dependence on growth state of backup pathways of NHEJ
Purpose: Backup pathways of nonhomologous end joining (B-NHEJ) enable cells to repair
DNA double-strand breaks (DSBs) when DNA-PK–dependent NHEJ (D-NHEJ) is …
DNA double-strand breaks (DSBs) when DNA-PK–dependent NHEJ (D-NHEJ) is …
Alternative non-homologous end-joining: mechanisms and targeting strategies in cancer
P Nagaria, FV Rassool - Targeting the DNA damage response for anti …, 2018 - Springer
Repair of DNA double-strand breaks (DSB) s is essential to the growth and survival of
normal as well as cancer cells. Alteration of DSB repair properties in cancer cells can not …
normal as well as cancer cells. Alteration of DSB repair properties in cancer cells can not …
Identification and characterization of mercaptopyrimidine‐based small molecules as inhibitors of nonhomologous DNA end joining
Mercaptopyrimidine derivatives are heterocyclic compounds with potent biological activities
including antiproliferative, antibacterial, and anti‐inflammatory properties. The present study …
including antiproliferative, antibacterial, and anti‐inflammatory properties. The present study …