It has been well-described that sickle cell disease (SCD) due to HbSS or HbSC is
associated with systemic activation of coagulation. A single study has reported a similar …

Chronic activation of coagulation is one of the features of sickle cell disease (SCD).
Increased tissue factor expression, phosphatidylserine exposure, thrombin generation and …

Sickle cell disease (SCD) is a group of inherited disorders characterized by the presence of
abnormal hemoglobin S. Patients with SCD suffer from frequent episodes of anemia, chronic …

Sickle cell disease is the most common inherited haematological disorder that leads to the
irreversible damage of multiple organs. Although sickling of red blood cells and vaso …

Sickle cell disease (SCD) is an inherited monogenic red blood cell disorder affecting
millions worldwide. SCD causes vascular occlusions, chronic hemolytic anemia, and …

Recent epidemiologic data suggest that sickle cell trait (Hb AS; AS) is a risk factor for venous
thromboembolism. We conducted an exploratory study of healthy subjects with AS under …

Sickle cell disease (SCD) is a hypercoagulable state. Patients exhibit increased platelet
activation, high plasma levels of markers of thrombin generation, depletion of natural …

Sickle cell disease (SCD) is an inherited condition characterized by chronic haemolytic
anaemia. SCD is associated with moderate to severe anaemia, hypercoagulable state and …

Sickle cell disease (SCD) is an inherited hemoglobinopathy that is caused by the presence
of abnormal hemoglobin S (HbS) in red blood cells, leading to alterations in red cell …

The prothrombotic nature of sickle cell disease (SCD) is evidenced by the chronically
elevated levels of almost all coagulation activation biomarkers, and an increased incidence …