The provisional criteria proposed in 1985 by Khachaturian et al. emphasized numbers of
plaques and neglected tangles, as did CERAD (Consortium to Establish a Registry for …

In an attempt to gather information on procedures, criteria, and possible difficulties, we have
sent a detailed questionnaire on the postmortem diagnosis of Alzheimer disease (AD) to 169 …

The unequivocal diagnosis of Alzheimer disease (AD) rests on histopathological evidence at
brain autopsy or biopsy. Although the histological features of AD are well known, defining …

The lesions of Alzheimer disease (AD) consist of synapse and neuron loss associated with
progressive deposition of amyloid as diffuse and neuritic plaques and accumulating tau …

These 2 neuropathological hallmarks have been the cornerstone of neuropathological
diagnosis ever since. However, since a few of these lesions are detected in most individuals …

The title of this paper is open to four different interpretations:(a)" clinico-pathological
correlation" as the verification (or falsification) of a clinical diagnosis of" probable" or" …

The diagnosis of dementia of the Alzheimer type in living patients is a clinical judgment
based upon careful neurological and neuropsychological examination combined with …

The neuropathological diagnosis of Alzheimer's disease currently relies on quantitative or
semiquantitative criteria of senile or neuritic plaques that are adjusted for age and for the …

• An 82-year-old cognitively healthy man was assessed longitudinally until very mild senile
dementia of the Alzheimer type was diagnosed by clinical research criteria and documented …

The histopathologic changes distinguishing early Alzheimer disease (AD) from normal or
pathologic aging arc not clearly defined. This report describes the autopsy findings of 59 …