Studies have suggested that integration of kinase and phosphatase activities maintains the
steady‐state L‐type Ca2+ current in ventricular myocytes, a balance disrupted in failing …

We examined the role of the Ca2+‐regulated protein phosphatase calcineurin in controlling
Ca2+ signalling in mouse ventricular myocytes. Membrane currents and voltage were …

The goal of this study was to determine whether the protein kinase A (PKA) responsiveness
of the cardiac L-type Ca2+ current (I Ca) is affected during transient increases in intracellular …

The intracellular mechanism underlying the Ca (2+)-induced enhancement of the L-type
Ca2+ current (ICa) was examined in adult rabbit cardiac ventricular myocytes by using patch …

Calyculin A was used to examine the importance of phosphatases in the modulation of
cardiac contractile magnitude in the absence of any neural or humoral stimulation. Protein …

Calcium entry through voltage-gated Ca2+ channels is critical in cardiac excitation-
contraction coupling and calcium metabolism. In this report, we demonstrate both spatially …

We have previously shown that whole-cell L-type Ca2+ current that was stimulated through
β-adrenergic receptors was negatively modulated by α1-adrenergic activation. In the present …

Pharmacological inhibitors of protein kinase A (PKA) and protein phosphatases 1/2A were
used to determine whether basal L-type Ca 2+ current (I Ca) observed in the absence of …

Calcium currents (ICa) and barium currents (IBa) were measured in freshly isolated single
ferret ventricular myocytes, using the whole cell patch-clamp and perforated patch-clamp …

Inactivation of the L-type Ca2+ current (I CaL) was studied in isolated guinea pig ventricular
myocytes with different ionic solutions. Under basal conditions, I CaL of 82% of cells infused …