Unlocking fungal cryptic natural products

YM Chiang, KH Lee, JF Sanchez… - Natural product …, 2009 - journals.sagepub.com
Recent published sequencing of fungal genomes has revealed that these microorganisms
have a surprisingly large number of secondary metabolite pathways that can serve as …

From genomics to metabolomics, moving toward an integrated strategy for the discovery of fungal secondary metabolites

T Hautbergue, EL Jamin, L Debrauwer, O Puel… - Natural Product …, 2018 - pubs.rsc.org
Fungal secondary metabolites are defined by bioactive properties that ensure adaptation of
the fungus to its environment. Although some of these natural products are promising …

Fungal natural products galaxy: Biochemistry and molecular genetics toward blockbuster drugs discovery

K Bhattarai, ME Kabir, R Bastola, B Baral - Advances in genetics, 2021 - Elsevier
Secondary metabolites synthesized by fungi have become a precious source of inspiration
for the design of novel drugs. Indeed, fungi are prolific producers of fascinating, diverse …

Unearthing fungal chemodiversity and prospects for drug discovery

C Greco, NP Keller, A Rokas - Current opinion in microbiology, 2019 - Elsevier
Highlights•Fungi are an excellent source of drugs, and their full potential in producing
different metabolites is still largely untapped.•Several heterologous platforms have been …

Biologically active secondary metabolites from the fungi

GF Bills, JB Gloer - Microbiology spectrum, 2016 - Am Soc Microbiol
Many Fungi have a well-developed secondary metabolism. The diversity of fungal species
and the diversification of biosynthetic gene clusters underscores a nearly limitless potential …

Engineering fungal secondary metabolism: a roadmap to novel compounds

DH Scharf, AA Brakhage - Journal of biotechnology, 2013 - Elsevier
Natural products play important roles not only in the environment but also as useful
compounds in various applications like in medicine or plant protection. An enormous …

Strategies for natural product discovery by unlocking cryptic biosynthetic gene clusters in fungi

JY Hur, E Jeong, YC Kim, SR Lee - Separations, 2023 - mdpi.com
Recent advancements in genome sequencing and bioinformatic analysis of fungal genomes
have revealed that fungi possess cryptic or silent biosynthetic gene clusters (BGCs). This …

Fungal secondary metabolites in the “OMICS” Era

S Zeilinger, C García-Estrada, JF Martín - Biosynthesis and Molecular …, 2015 - Springer
Secondary metabolites produced by fungi have a tremendous impact on the human society;
some are exploited for their antibiotic and pharmaceutical activities, others are involved in …

Strategies for mining fungal natural products

P Wiemann, NP Keller - Journal of Industrial Microbiology and …, 2014 - academic.oup.com
Fungi are well known for their ability to produce a multitude of natural products. On the one
hand their potential to provide beneficial antibiotics and immunosuppressants has been …

Deciphering chemical logic of fungal natural product biosynthesis through heterologous expression and genome mining

CY Chiang, M Ohashi, Y Tang - Natural product reports, 2023 - pubs.rsc.org
Covering: 2010 to 2022 Heterologous expression of natural product biosynthetic gene
clusters (BGCs) has become a widely used tool for genome mining of cryptic pathways …