Estimating genomic distance from DNA sequence location in cell nuclei by a random walk model
G Van den Engh, R Sachs, BJ Trask - Science, 1992 - science.org
The folding of chromatin in interphase cell nuclei was studied by fluorescent in situ
hybridization with pairs of unique DNA sequence probes. The sites of DNA sequences …
hybridization with pairs of unique DNA sequence probes. The sites of DNA sequences …
Evidence for the organization of chromatin in megabase pair-sized loops arranged along a random walk path in the human G0/G1 interphase nucleus.
H Yokota, G Van Den Engh, JE Hearst… - The Journal of cell …, 1995 - rupress.org
We determined the folding of chromosomes in interphase nuclei by measuring the distance
between points on the same chromosome. Over 25,000 measurements were made in G0/G1 …
between points on the same chromosome. Over 25,000 measurements were made in G0/G1 …
Capturing chromosome conformation
We describe an approach to detect the frequency of interaction between any two genomic
loci. Generation of a matrix of interaction frequencies between sites on the same or different …
loci. Generation of a matrix of interaction frequencies between sites on the same or different …
Cross-linking of DNA in situ as a probe for chromatin structure
CV Hanson, C Shen, JE Hearst - Science, 1976 - science.org
The photochemical cross-linking of DNA in situ in chromatin is blocked over short intervals.
Electron microscopy of DNA cross-linked in chromatin reveals the lengths of protected …
Electron microscopy of DNA cross-linked in chromatin reveals the lengths of protected …
Ordered Restriction Maps of Saccharomyces cerevisiae Chromosomes Constructed by Optical Mapping
DC Schwartz, X Li, LI Hernandez, SP Ramnarain… - Science, 1993 - science.org
A light microscope-based technique for rapidly constructing ordered physical maps of
chromosomes has been developed. Restriction enzyme digestion of elongated individual …
chromosomes has been developed. Restriction enzyme digestion of elongated individual …
The proximity of DNA sequences in interphase cell nuclei is correlated to genomic distance and permits ordering of cosmids spanning 250 kilobase pairs
B Trask, D Pinkel, G van den Engh - Genomics, 1989 - Elsevier
The physical distance between DNA sequences in interphase nuclei was determined using
eight cosmids containing fragments of the Chinese hamster genome that span 273 kb …
eight cosmids containing fragments of the Chinese hamster genome that span 273 kb …
Yeast chromatin subunit structure
D Lohr, KE Van Holde - Science, 1975 - science.org
Micrococcal nuclease digestion of in situ (intranuclear) and in vitro yeast chromatin
produces distributions of DNA molecules of discrete sizes. In both cases, these molecules …
produces distributions of DNA molecules of discrete sizes. In both cases, these molecules …
Detection of DNA sequences in nuclei in suspension by in situ hybridization and dual beam flow cytometry
B Trask, G Van Den Engh, J Landegent, NJ in de Wal… - Science, 1985 - science.org
This report describes the fluorescence hybridization of DNA sequence probes to interphase
nuclei in suspension and the quantification of bound probe by dual beam flow cytometry …
nuclei in suspension and the quantification of bound probe by dual beam flow cytometry …
Chromosome dynamics in the yeast interphase nucleus
Little is known about the dynamics of chromosomes in interphase nuclei. By tagging four
chromosomal regions with a green fluorescent protein fusion to lac repressor, we monitored …
chromosomal regions with a green fluorescent protein fusion to lac repressor, we monitored …
Localization of sister chromatid exchanges in human chromosomes
SA Latt - Science, 1974 - science.org
The bromodeoxyuridine sensitivity of 33258 Hoechst fluorescence allows microfluorometric
analysis of sister chromatid exchanges in human metaphase chromosomes. The frequency …
analysis of sister chromatid exchanges in human metaphase chromosomes. The frequency …