Following activation, macrophages undergo extensive metabolic rewiring,. Production of
itaconate through the inducible enzyme IRG1 is a key hallmark of this process. Itaconate …

Remodeling of the tricarboxylic acid (TCA) cycle is a metabolic adaptation accompanying
inflammatory macrophage activation. During this process, endogenous metabolites can …

Itaconate is a unique regulatory metabolite that is induced upon Toll-like receptor (TLR)
stimulation in myeloid cells. Here, we demonstrate major inflammatory tolerance and cell …

The Krebs cycle-derived metabolite itaconate is highly upregulated in inflammatory
macrophages and exerts immunomodulatory effects through cysteine modifications on target …

Although the immunomodulatory and cytoprotective properties of itaconate have been
studied extensively, it is not known whether its naturally occurring isomers mesaconate and …

Macrophages exposed to inflammatory stimuli including LPS undergo metabolic
reprogramming to facilitate macrophage effector function. This metabolic reprogramming …

Metabolic regulation has been recognized as a powerful principle guiding immune
responses. Inflammatory macrophages undergo extensive metabolic rewiring marked by the …

Macrophages play a central role in innate immunity as the first line of defense against
pathogen infection. Upon exposure to inflammatory stimuli, macrophages rapidly respond …

Itaconate is one of the best examples of the consequences of metabolic reprogramming
during immunity. It is made by diverting aconitate away from the tricarboxylic acid cycle …

The Krebs cycle-derived metabolite itaconate, whose production is catalyzed by immune
response gene 1 (IRG1), has potential to link immunity and metabolism in activated …