Moderately elevated plasma total homocysteine (tHcy) is a strong modifiable risk factor for
vascular dementia and Alzheimer's disease. Prospectively, elevated tHcy is associated with …

Background Evidence supports an independent association between plasma total
homocysteine concentrations and the risk of vascular disease. Recent epidemiologic studies …

Elevated plasma homocysteine (Hcy) concentrations have been implicated with risk of
cognitive impairment and dementia, but it is unclear whether low vitamin B12 or folate status …

Identification of modifiable risk factors provides a crucial approach to the prevention of
dementia. Nutritional or nutrient-dependent risk factors are especially important because …

Background: High concentrations of homocysteine have been linked to a greater risk of
Alzheimer disease, dementia, and cognitive decline. Objective: We evaluated the …

Dementia has reached epidemic proportions, with an estimated 4.6 million new cases
worldwide each year. With an aging world population, the prevalence of dementia will …

Context Blood levels of homocysteine may be increased in Alzheimer disease (AD) and
hyperhomocysteinemia may contribute to disease pathophysiology by vascular and direct …

See corresponding article on page 908. cycle in hippocampal neurons, a plausible
precursor of apoptosis and of Alzheimer-type pathology (23). The finding that vascular …

Elevated total plasma homocysteine has been linked to the development of cognitive
impairment and dementia in later life and this can be reliably lowered by the daily …

INTRODUCTION: Whether homocysteine lowering by B vitamins can reduce cognitive
decline in Alzheimer disease and vascular dementia patients is unclear. METHODS AND …