Protein–protein associations, ie formation of permanent or transient protein complexes, are
essential for protein functionality and regulation within the cellular context. Peroxiredoxins …

Abstract Significance: Hydrogen peroxide (H2O2) is known to act as a messenger in signal
transduction. How H2O2 leads to selective and efficient oxidation of specific thiols on …

Abstract Peroxiredoxins (Prx), thiol-dependent peroxidases, were first identified as H 2 O 2
detoxifiers, and more recently as H 2 O 2 sensors, intermediates in redox-signaling …

The peroxiredoxins are a ubiquitous family of proteins involved in protection against
oxidative stress through the detoxification of cellular peroxides. In addition, the typical 2-Cys …

Redox signaling is controlled by the reversible oxidation of cysteine thiols, a post-
translational modification triggered by H2O2 acting as a second messenger. However …

Reversible protein glutathionylation, a redox-sensitive regulatory mechanism, plays a key
role in cellular regulation and cell signaling. Peroxiredoxins (Prxs), a family of peroxidases …

2-Cys peroxiredoxins belonging to the Prx1 subfamily are Cys-based peroxidases that
control the intracellular levels of H 2 O 2 and seem to assume a chaperone function under …

Peroxiredoxins (Prxs) are a ubiquitous family of antioxidant enzymes that also control
cytokine-induced peroxide levels which mediate signal transduction in mammalian cells …

Peroxiredoxins (Prxs) are a ubiquitous family of cysteine-dependent peroxidase enzymes
that play dominant roles in regulating peroxide levels within cells. These enzymes, often …

Peroxiredoxins (Prdxs) sense and assess peroxide levels, and signal through protein
interactions. Understanding the role of the multiple structural and post-translational …