B cells in Sjögren's syndrome: from pathophysiology to therapeutic target

J Mielle, A Tison, D Cornec, L Le Pottier, C Daien… - …, 2021 - academic.oup.com
Biological abnormalities associated with B lymphocytes are a hallmark of patients with
primary Sjögren's syndrome. Those patients present abnormal distribution of B lymphocytes …

B cells in the pathogenesis of primary Sjögren syndrome

G Nocturne, X Mariette - Nature Reviews Rheumatology, 2018 - nature.com
Primary Sjögren syndrome (pSS) is a prototypical autoimmune disease. The involvement of
B cells in the pathogenesis of pSS has long been suspected on the basis of clinical …

A conspicuous role for B cells in Sjögren's syndrome

P Youinou, V Devauchelle, P Hutin, R Le Berre… - Clinical reviews in …, 2007 - Springer
Although the relative contributions of T cells and B cells in Sjögren's syndrome (SS) are far
from being settled, recent studies have suggested a crucial role for B cells in its …

B cells in Sjögren's syndrome: from pathophysiology to diagnosis and treatment

D Cornec, V Devauchelle-Pensec, GJ Tobón… - Journal of …, 2012 - Elsevier
Primary Sjögren's syndrome (pSS) is a chronic autoimmune systemic disease, characterized
by a lymphoplasmocytic infiltration and a progressive destruction of salivary and lachrymal …

The future of B cell-targeted therapies in Sjögren's syndrome

D Cornec, A Saraux, V Devauchelle-Pensec… - …, 2013 - Taylor & Francis
Primary Sjögren's syndrome is a systemic autoimmune disease characterized by
progressive exocrine gland destruction, resulting clinically in eyes and mouth dryness. To …

Therapeutic potential for B-cell modulation in Sjögren's syndrome

X Mariette - Rheumatic Disease Clinics of North America, 2008 - Elsevier
Therapeutic Potential for B-Cell Modulation in Sjögren's Syndrome - ScienceDirect Skip to
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Treating Sjögren's syndrome: insights for the clinician

C Vitali, G Palombi, P Cataleta - Therapeutic Advances in …, 2010 - journals.sagepub.com
Sjögren's syndrome (SS) is a systemic autoimmune disease that affects the exocrine glands,
mainly the salivary and lachrymal glands, with consequent persistent dryness of the mouth …

T cells in primary Sjögren's syndrome: targets for early intervention

GM Verstappen, FGM Kroese, H Bootsma - Rheumatology, 2021 - academic.oup.com
A histologic hallmark of primary SS (pSS) is lymphocytic infiltration of the salivary and
lacrimal glands, in particular by CD4+ T and B cells. In the early stages of the disease …

Sjögren's syndrome—A plethora of clinical and immunological phenotypes with a complex genetic background

R Jonsson, AI Bolstad, KA Brokstad… - Annals of the New York …, 2007 - Wiley Online Library
Primary Sjögren's syndrome is a complex autoimmune disorder, considered to represent an
ideal disease with which to study the mechanisms underlying autoimmunity because its …

[PDF][PDF] Role of B cells in Sjogren's syndrome–from benign lymphoproliferation to overt malignancy

R Jonsson, E Nginamau, E Szyszko, KA Brokstad - Front Biosci, 2007 - article.imrpress.com
Introduction 3. Characteristics of human B cells 4. The lymphoepithelial lesion and germinal
centers in Sjögren's syndrome 5. Autoantibodies in diagnosis and pathogenesis 6 …