The most predictable cause of failure of a biological prosthetic heart valve is calcification.
The deposition process appears to be related both to the biomaterial composition and to the …

The lifetime of bioprosthetic heart valves is limited by primary tissue failure and calcification
of the valve leaflets. There are indications that synthetic elastomeric materials may also be …

There is a strong relationship between mechanical stress and calcification in biological
prosthetic heart valves. A dynamic in vitro calcification test has been used to study the …

This study has examined a range of methods of studying the calcification process in bovine
pericardial and polyurethane biomaterials. The calcification methods include static and …

Previous work in our laboratory has demonstrated a simple, dynamic in vitro calcification
method for studying bovine pericardial heart valves. The calcification produced closely …

Calcification of bioprostheses used for heart valve replacement is a serious problem, since it
causes bioprosthetic dysfunction. In vivo, bioprostheses are subjected to large mechanical …

Methods Four bovine pericardial and two porcine mitral valves (Baxter) with a tissue annulus
diameter (TAD) of 29 mm (one 27 mm) were investigated in parallel under identical test …

Calcification is a major reason for the failure of bioprosthetic heart valves. Therefore, several
attempts towards an accelerated in vitro model were undertaken in order to provide a cost …

Calcification, the major cause of bioprosthetic heart valve failures, is a serious clinical
problem with uncertain pathogenesis. The objectives of the present study were to define the …

To investigate the calcification behavior of different bioprosthetic heart valves and verify
possible hypotheses of the etiology of valve calcification, an accelerated pulse tester for …