Objective Whereas cognitive deficits are known to be detectable long before the typical
symptoms of Alzheimer's disease (AD) are evident, previous studies have failed to …

Objective To characterize the course of cognitive decline during the prodromal phase of
Alzheimer disease. Design Longitudinal cohort study with up to 16 years of observation …

Objectives: To observe the natural time course of noncognitive symptoms before the onset of
symptomatic Alzheimer disease dementia. Methods: Using the National Alzheimer's …

The hypothesis that mild cognitive impairment (MCI) represents an early stage of
Alzheimer's disease (AD) was investigated by reviewing recent research from three sources …

Objective: To determine if individuals ultimately diagnosed with Alzheimer disease (AD)
exhibited evidence of cognitive impairment on neuropsychological tests administered …

Two subtypes of Alzheimer's disease (AD) have been commonly identified: early-and late-
onset forms. Previous studies suggest that early-onset AD patients have more neuritic …

Objectives To examine the ability of the total score and individual items from the Mini-Mental
State Examination in predicting the development of Alzheimer disease (AD) across a 3-and …

We review the literature on cognitive functioning during the transition from normal aging to
clinical Alzheimer's disease (AD). There is ample empirical evidence that deficits across …

Background To understand the earliest signs of cognitive decline caused by Alzheimer
disease (AD) and other illnesses causing dementia, information is needed from well …

Objective Some individuals who are asymptomatic for dementia while alive have substantial
Alzheimer's disease (AD) neuropathology at autopsy. We investigated whether cognitive …