Cell-free DNA provides a good representation of the tumor genome despite its biased fragmentation patterns

X Ma, L Zhu, X Wu, H Bao, X Wang, Z Chang… - PloS one, 2017 - journals.plos.org
Cell-free DNA (cfDNA) is short, extracellular, fragmented double-stranded DNA found in
plasma. Plasma of patients with solid tumor has been found to show significantly increased …

Clinical relevance of cell-free DNA in gastrointestinal tract malignancy

YT Lan, MH Chen, WL Fang, CC Hsieh, CH Lin… - …, 2016 - pmc.ncbi.nlm.nih.gov
Background Cell-free DNA (cfDNA) extracted from blood has become a clinically feasible
biomarker in various types of cancer. However, the clinical significance of cfDNA in …

Multi-modal cell-free DNA genomic and fragmentomic patterns enhance cancer survival and recurrence analysis

N Moldovan, Y van der Pol, T van den Ende… - Cell Reports …, 2024 - cell.com
The structure of cell-free DNA (cfDNA) is altered in the blood of patients with cancer. From
whole-genome sequencing, we retrieve the cfDNA fragment-end composition using a new …

Genomic variations in plasma cell free DNA differentiate early stage lung cancers from normal controls

S Xia, CC Huang, M Le, R Dittmar, M Du, T Yuan… - Lung Cancer, 2015 - Elsevier
Objectives Cell free tumor DNA (cfDNA) circulating in blood has a great potential as
biomarker for cancer clinical management. The objective of this study is to evaluate if cfDNA …

Quantitative characterization of tumor cell-free DNA shortening

J Guo, K Ma, H Bao, X Ma, Y Xu, X Wu, YW Shao… - BMC genomics, 2020 - Springer
Background Previous studies found that cell-free DNA (cfDNA) generated from tumors was
shorter than that from healthy cells, and selecting short cfDNA could enrich for tumor cfDNA …

Cell-free DNA: hope and potential application in cancer

Y Yan, Q Guo, F Wang, R Adhikari, Z Zhu… - Frontiers in cell and …, 2021 - frontiersin.org
Cell-free DNA (cfDNA) is easily accessible in peripheral blood and can be used as
biomarkers for cancer diagnostics, prognostics, and therapeutics. The applications of cfDNA …

Collection of cell-free DNA for genomic analysis of solid tumors in a clinical laboratory setting

CK Raymond, J Hernandez, R Karr, K Hill, M Li - PloS one, 2017 - journals.plos.org
The breadth of diagnostic procedures that utilize cell free DNA (cfDNA) from human plasma
has increased dramatically in recent years. Here, we confirm that tumor-derived cfDNA …

Size distribution of cell-free DNA in oncology

S Udomruk, S Orrapin, D Pruksakorn… - Critical reviews in …, 2021 - Elsevier
Tumor-specific, circulating cell-free DNA (cfDNA) in liquid biopsy test is a novel promising
biomarker in the advancement of cancer management, including early diagnosis, screening …

Low-coverage whole genome sequencing of cell-free DNA from immunosuppressed cancer patients enables tumor fraction determination and reveals relevant copy …

A Bouzidi, K Labreche, M Baron, M Veyri… - Frontiers in Cell and …, 2021 - frontiersin.org
Cell-free DNA (cfDNA) analysis is a minimally invasive method that can be used to detect
genomic abnormalities by directly testing a blood sample. This method is particularly useful …

Genome-wide cell-free DNA termini in patients with cancer

N Moldovan, Y van der Pol, T van den Ende, D Boers… - medRxiv, 2021 - medrxiv.org
The structure, fragmentation pattern, length and terminal sequence of cell-free DNA (cfDNA)
is under the influence of nucleases present in the blood. We hypothesized that differences in …