Foxp3 is a transcription factor required for the development of regulatory T cells (Treg). Mice
and humans with a loss of Foxp3 function suffer from uncontrolled autoimmunity and …

The forkhead/winged-helix transcription factor FOXP3 confers suppressive ability to CD4+
FOXP3+ regulatory T (Treg) cells. Human Treg cells express several different isoforms of …

Regulatory T cells (Tregs) act in trans to control immune responses. The suppressive
function of Tregs relies heavily on high and stable expression of the transcription factor …

Differing from the mouse Foxp3 gene that encodes only one protein product, human FOXP3
encodes two major isoforms through alternative splicing—a longer isoform (FOXP3 FL) …

Regulatory T (Treg) cells are essential in preventing the host from developing certain
autoimmune diseases and limiting excessive immune responses against pathogens. The …

Foxp3 has been shown to be both necessary and sufficient for the development and function
of naturally arising CD4+ CD25+ regulatory T cells in mice. Mutation of Foxp3 in Scurfy mice …

CD4+ regulatory T cells (Treg cells) characterized by expression of the transcription factor
Foxp3 have a pivotal role in maintaining immunological tolerance. Here we show that mice …

Foxp3, an X chromosome–encoded forkhead transcription factor family member, is
indispensable for the differentiation of regulatory T cells. These cells have a vital role in …

Regulatory T cells that express the Foxp3 transcription factor play important roles in
preventing autoimmune diseases. Although several studies have demonstrated that the lack …

Foxp3 is a 47-kDa transcription factor central to regulatory T cell (Treg) function. The
importance of Foxp3+ Tregs in controlling self-reactive T cells and preventing autoimmunity …