Traditional working heart preparations, based on the original Langendorff setup, are widely
used experimental models that have tremendously advanced the cardiovascular field …

Use of the zebrafish model system for studying development, regeneration, and disease is
expanding toward use of adult hearts for cell dissociation and purification of RNA, DNA, and …

Zebrafish are increasingly used as a vertebrate model to study human cardiovascular
disorders. Although heart structure and function are readily visualized in zebrafish embryos …

Since its introduction in the late 19th century, the Langendorff isolated heart perfusion
apparatus, and the subsequent development of the working heart model, have been …

The zebrafish is increasingly used for cardiovascular genetic and functional studies. We
present a novel protocol to maintain and monitor whole isolated beating adult zebrafish …

Have a Heart Obtaining pure organ preparation by microdissection from small organisms,
such as the zebrafish, Dario rerio, is itself a sufficiently arduous task. Isolating such organs in …

Heart transplantation became a reality at the end of the 1960s as a life-saving option for
patients with end-stage heart failure. Static cold storage (SCS) at 4–6° C has remained the …

In the last two decades, the zebrafish has emerged as an important model species for heart
regeneration studies. Various approaches to model loss of cardiac myocytes and myocardial …

Myocardial infarction and heart failure are leading causes of death worldwide, in large part
because adult human myocardium has extremely limited regeneration capacity. Zebrafish …

The adult zebrafish heart provides a powerful model in cardiac regeneration research.
Although the strength of this system is based on transgenic approaches, a rapid delivery of …