Importance Late-life depression (LLD) is characterized by considerable heterogeneity in
clinical manifestation. Unraveling such heterogeneity might aid in elucidating etiological …

Objective Currently, depression diagnosis relies primarily on behavioral symptoms and
signs, and treatment is guided by trial and error instead of evaluating associated underlying …

Background Major depressive disorder (MDD) is a disabling mood disorder, and despite a
known heritable component, a large meta-analysis of genome-wide association studies …

Objective: Structural neuroimaging findings in younger and older adults with major
depressive disorder (MDD) are highly heterogeneous, possibly as a result of methodological …

Importance Identifying neurobiological differences between patients with major depressive
disorder (MDD) and healthy individuals has been a mainstay of clinical neuroscience for …

Major depressive disorder (MDD) is associated with an increased risk of brain atrophy,
aging-related diseases, and mortality. We examined potential advanced brain aging in adult …

Late-life depression (LLD) is thought to be multifactorial in etiology, including a significant
genetic component. While a number of candidate gene studies have been carried out …

The phenomenologic diagnosis of depression is successful in increasing diagnostic
reliability, but it is a classification scheme without biologic bases. One subtype of depression …

Importance Despite the moderate, well-demonstrated heritability of major depressive
disorder (MDD), there has been limited success in identifying replicable genetic risk loci …

Background Most patients with late-life depression (LLD) have cognitive impairment, and at
least one-third meet diagnostic criteria for mild cognitive impairment (MCI), a prodrome to …