Mitochondrial polarisation status and [Ca2+] i signalling in rat cerebellar granule neurones aged in vitro

J Xiong, PJ Camello, A Verkhratsky, EC Toescu - Neurobiology of aging, 2004 - Elsevier
Mitochondrial membrane potential is a major factor that controls, ultimately, the cellular
energy supply. By use of a mitochondrial membrane potential dye (rhodamine 123, R123) …

Changes in mitochondrial status associated with altered Ca2+ homeostasis in aged cerebellar granule neurons in brain slices

J Xiong, A Verkhratsky, EC Toescu - Journal of Neuroscience, 2002 - Soc Neuroscience
In the present work, we investigated the relationship between mitochondrial function and
Ca2+ homeostasis in brain slices obtained from mice that aged normally. In acute …

Ca2+- and Metabolism-Related Changes of Mitochondrial Potential in Voltage-Clamped CA1 Pyramidal Neurons In Situ

S Schuchmann, M Luckermann… - Journal of …, 2000 - journals.physiology.org
In hippocampal slices from rats, dialysis with rhodamine-123 (Rh-123) and/or fura-2 via the
patch electrode allowed monitoring of mitochondrial potential (ΔΨ) changes and …

Spontaneous changes in mitochondrial membrane potential in cultured neurons

JF Buckman, IJ Reynolds - Journal of Neuroscience, 2001 - Soc Neuroscience
Using the mitochondrial membrane potential (ΔΨm)-sensitive fluorescent dyes 5, 5′, 6, 6′-
tetrachloro-1, 1′, 3, 3′-tetraethylbenzimidazolocarbocyanine iodide (JC-1) and …

Ca2+-dependent changes in the mitochondrial energetics in single dissociated mouse sensory neurons

MR Duchen - Biochemical Journal, 1992 - portlandpress.com
Depolarization of neurons promotes Ca2+ influx through voltage-activated channels, raising
the intracellular Ca2+ concentration ([Ca2+] i). The consequences of such changes in …

Reduced mitochondrial buffering of voltage-gated calcium influx in aged rat basal forebrain neurons

D Murchison, DC Zawieja, WH Griffith - Cell Calcium, 2004 - Elsevier
Alterations of neuronal Ca2+ homeostatic mechanisms could be responsible for many of the
cognitive deficits associated with aging in mammals. Mitochondrial participation in Ca2+ …

Blockade of mitochondrial Ca2+ uptake by mitochondrial inhibitors amplifies the glutamate‐induced calcium response in cultured cerebellar granule cells

B Khodorov, V Pinelis, T Storozhevykh… - FEBS …, 1999 - Wiley Online Library
The objective of this study was to evaluate the role of mitochondrial Ca2+ uptake (MCU) in
modulation (shaping) of the glutamate (Glu)‐induced changes in neuronal cytoplasmic …

Swelling of mitochondria in cultured rat hippocampal astrocytes is induced by high cytosolic Ca2+ load, but not by mitochondrial depolarization

S Kahlert, G Reiser - FEBS letters, 2002 - Wiley Online Library
The influence of cytosolic Ca2+ load and of mitochondrial membrane potential change on
mitochondrial morphology was investigated in cultured rat hippocampal astrocytes. The …

Reduced calcium uptake by rat brain mitochondria and synaptosomes in response to aging

SW Leslie, LJ Chandler, EM Barr, RP Farrar - Brain research, 1985 - Elsevier
Synaptosomes were isolated from cerebral cortex of 3-, 18-and 24-month-old male, Fisher
344 rats and 45 Ca 2+ uptake was measured at 1, 3, 5 and 30 s time periods following 65 …

Mitochondrial membrane potential measurement in rat cerebellar neurons by flow cytometry

FX Sureda, E Escubedo, C Gabriel… - … : The Journal of the …, 1997 - Wiley Online Library
Mitochondrial membrane potential (MMP) in dissociated rat cerebellar neurons was
measured using rhodamine 123 (Rh 123) as fluorescent dye, and flow cytometry. Dye …