Introduction of DNA sequences into the genome often results in homology-dependent gene
silencing in organisms as diverse as plants, fungi, flies, nematodes, and mammals. We …

Cosuppression is a silencing phenomenon triggered by the introduction of homologous
DNA sequences into the genomes of organisms as diverse as plants, fungi, flies, and …

RNA interference (RNAi) is an experimental technique used to suppress individual gene
expression in eukaryotic cells in a sequence-dependent manner. The process relies on …

Cryptococcus neoformans is a human fungal pathogen that undergoes a dimorphic
transition from yeast to hyphae during a-α opposite-sex mating and α-α unisexual …

Cryptococcus neoformans is a pathogenic fungus responsible for serious disease in
immunocompromised individuals. This organism has recently been developed as an …

Adaptation to external environmental challenges at the cellular level requires rapid
responses and involves relay of information to the nucleus to drive key gene expression …

The RNA interference (RNAi) mediated by homology-dependent degradation of the target
mRNA with small RNA molecules plays a key role in controlling transcription and translation …

While increased mutation rates typically have negative consequences in multicellular
organisms, hypermutation can be advantageous for microbes adapting to the environment …

RNAi is a ubiquitous pathway that serves central functions throughout eukaryotes, including
maintenance of genome stability and repression of transposon expression and movement …

The notion that the structure and behavior of an organism are determined primarily by the
structure and behavior of the organism's genome is well accepted. Lamarckism aside, it is …