The molecular neurobiology of depression begins with the concept that depressive
disorders represent a family of related but distinct conditions. Different points of vulnerability …

Major depressive disorder is a heritable psychiatric syndrome that appears to be associated
with subtle cellular and molecular alterations in a complex neural network. The affected …

The underlying causes of most mood and anxiety disorders remain unknown. There is a
strong heritable component to psychiatric illnesses that, when coupled with environmental …

The past 5 years have seen unprecedented advances in our knowledge about the
neurobiology of depression. Significant breakthroughs have been made in genomics …

Recent studies have begun to characterize the actions of stress and antidepressant
treatments beyond the neurotransmitter and receptor level. This work has demonstrated that …

Current treatments for depression are inadequate for many individuals, and progress in
understanding the neurobiology of depression is slow. Several promising hypotheses of …

Extensive studies have led to a variety of hypotheses for the molecular basis of depression
and related mood disorders, but a definite pathogenic mechanism has yet to be defined. The …

Major depressive disorder (MDD) is a common and disabling disorder that carries both a
substantial personal burden as well as a social one. A better understanding of the …

Previously, authors have reviewed the evidence pertaining to a wide range of
neurochemical, neuroendocrine, neurophysiological, and structural correlates of …

Major depressive disorders, long considered to be of neurochemical origin, have recently
been associated with impairments in signaling pathways that regulate neuroplasticity and …