Genetic factors underlying trait neuroticism, reflecting a tendency towards negative affective
states, may overlap genetic susceptibility for anxiety disorders and help explain the …

Objectives To summarise SNP associations identified by genome-wide association studies
(GWASs) of anxiety disorders and neuroticism; to appraise the quality of individual studies …

We leveraged information from more than 1.2 million participants, including 97,383 cases, to
investigate the genetics of anxiety disorders across five continental groups. Through …

Context Neuroticism is a trait that reflects a tendency toward negative mood states. It has
long been linked to internalizing psychiatric conditions, such as anxiety and depression, and …

Genome-wide association studies (GWAS) of psychological traits are generally conducted
on (dichotomized) sums of items or symptoms (eg, case-control status), and not on the …

Neuroticism is an important risk factor for psychiatric traits, including depression, anxiety,,
and schizophrenia,–. At the time of analysis, previous genome-wide association studies …

Neuroticism is a relatively stable personality trait characterized by negative emotionality (for
example, worry and guilt); heritability estimated from twin studies ranges from 30 to 50 …

Objective: Anxiety disorders are common and often disabling. The goal of this study was to
examine the genetic architecture of anxiety disorders and anxiety symptoms, which are also …

Anxiety disorders are one of the most common, debilitating and costly classes of psychiatric
disorders worldwide. Twin studies estimate heritability of anxiety disorders to be between …

Context People meeting diagnostic criteria for anxiety or depressive disorders tend to score
high on the personality scale of neuroticism. Studying this personality dimension can give …