While mutations in human FOXP3 predispose individuals to autoimmune conditions, it is
unclear how the mutant protein fails to function as a transcriptional regulator. There is also …

Regulatory T (Treg) cells are essential in preventing the host from developing certain
autoimmune diseases and limiting excessive immune responses against pathogens. The …

Foxp3, an X chromosome–encoded forkhead transcription factor family member, is
indispensable for the differentiation of regulatory T cells. These cells have a vital role in …

The discovery of the transcription factor Forkhead box-p3 (Foxp3) has shed fundamental
insights into the understanding of the molecular determinants leading to generation and …

FOXP3 is an acetylated and phosphorylated protein active in human regulatory T cells and
forms oligomers which then associate with an even larger molecular complex. FOXP3 …

Forkhead box (FOX) P3 is a requisite transcription factor for the development and
maintenance of immunosuppressive function of regulatory T (Treg) cells, and therefore for …

Differing from the mouse Foxp3 gene that encodes only one protein product, human FOXP3
encodes two major isoforms through alternative splicing—a longer isoform (FOXP3 FL) …

The immune system is responsible for not only eliminating threats to the body, but also for
protecting the body from its own immune responses that would cause harm if left unchecked …

The proper restraint of the destructive potential of the immune system is essential for
maintaining health. Regulatory T (Treg) cells ensure immune homeostasis through their …

Highlights•Dysregulation of FOXP3 expression can occur at multiple levels in autoimmunity.•
Autoimmune SNPs diminish IL-2 sensitivity and FOXP3, resulting in impaired …