We previously identified loci in the mouse genome that substantially influence the metastatic
efficiency of mammary tumors. Here, we present data supporting the idea that the signal …

Abstract SIPA1 (signal-induced proliferation-associated protein 1) is a GTPase activation
protein that can catalyze the hydrolysis of Rap1 bound GTP to GDP. Recently attention has …

Transcription factors (TFs) regulate the expression of genes responsible for cell growth,
differentiation, and responses to environmental factors. In this study, we demonstrated that …

Recent studies suggest that SIPA1 encoding a Rap GTPase‐activating protein SPA‐1 is a
candidate metastasis efficiency‐modifying gene in human breast cancer. In this study, we …

Metastasis suppressor genes (MSGs) have contributed to an understanding of regulatory
pathways unique to the lethal metastatic process. When re-expressed in experimental …

Previous work identified the Rap1 GTPase-activating protein Sipa1 as a germ-line-encoded
metastasis modifier. The bromodomain protein Brd4 physically interacts with and modulates …

Metastasis is the principal event leading to death in individuals with cancer, yet its molecular
basis is poorly understood 1. To explore the molecular differences between human primary …

Abstract Metastasis-associated protein 3 (MTA3) is a cell type-specific subunit of the Mi-
2/NuRD transcriptional corepressor complex. In breast cancer cells, MTA3 and the Mi …

SNAIL1 has been suggested to regulate breast cancer metastasis based on analyses of
human breast tumor transcriptomes and experiments using cancer cell lines and xenografts …

The molecular mechanisms and genetic programs required for cancer metastasis are
sometimes overlapping, but components are clearly distinct from those promoting growth of …