Innate immune cells are critical in protective immunity against viral infections, involved in
sensing foreign viral nucleic acids. Here we report that the poly (ADP-ribose) polymerase 9 …

Over 300 posttranslational modifications (PTMs) are known to modify the functions of
proteins by affecting processes ranging from activation, degradation, localization, secretion …

The enzymes of the poly-ADP-ribose polymerase (PARP) superfamily control many relevant
cellular processes, but a precise understanding of their activities in different physiological or …

PARP-catalysed ADP-ribosylation (ADPr) is important in regulating various cellular
pathways. Until recently, PARP-dependent mono-ADP-ribosylation has been poorly …

The poly (ADP-ribose) polymerases (PARPs) family contains 17 members in humans,
sharing a PARP domain to transfer ADP-ribose groups to target proteins to trigger ADP …

PARP7 is a monoPARP that catalyzes the transfer of single units of ADP-ribose onto
substrates to change their function. Here, we identify PARP7 as a negative regulator of …

Influenza A virus (IAV) utilizes multiple strategies to confront or evade host type I interferon
(IFN)-mediated antiviral responses in order to enhance its own propagation within the host …

The mono-ADP-ribosyltransferase PARP7 has emerged as a key negative regulator of
cytosolic NA-sensors of the innate immune system. We apply a rational design strategy for …

Outbreaks of viral infections are a global health burden. Although type I interferon (IFN-I)
exerts broad-spectrum antiviral effects, its antiviral efficacy in host cells is largely restricted …

PARP14 is a mono–ADP-ribosyl transferase involved in the control of immunity,
transcription, and DNA replication stress management. However, little is known about the …