Future prospects of anticytokine therapy in chronic heart failure

S von Haehling, SD Anker - Expert Opinion on Investigational …, 2005 - Taylor & Francis
Several lines of evidence suggest that chronic heart failure is a state of chronic inflammation.
Indeed, various pro-inflammatory markers, including the cytokines TNF-α, and interleukin 6 …

Anti-cytokine therapy in chronic heart failure: new approaches and unmet promises

T Bachetti, L Comini, E Pasini… - European heart journal …, 2004 - academic.oup.com
Until some decades ago chronic heart failure (CHF) has been considered a haemodynamic
disorder with neurohormonal activation. Thus, the therapeutic strategies were oriented to …

Anti-inflammatory trials in chronic heart failure.

P Aukrust, A Yndestad, T Ueland, JK Damås… - Heart Failure …, 2006 - europepmc.org
Chronic heart failure (CHF) is accompanied by a dysregulated cytokine network, which is
characterized by a rise in inflammatory cytokines and an inadequate elevation of anti …

Inflammatory mediators and the failing heart: a translational approach

A Diwan, T Tran, A Misra… - Current molecular …, 2003 - ingentaconnect.com
Recent studies have identified the importance of proinflammatory mediators in regulating
cardiac structure in health and disease. Recent studies suggest that cytokines that are …

Agents targeting inflammation in heart failure

L Gullestad, J Kjekshus, JK Damås… - Expert Opinion on …, 2005 - Taylor & Francis
Evidence from both experimental and clinical trials indicates that inflammatory mediators are
important in the pathogenesis of chronic heart failure (HF), contributing to cardiac …

Review of trials in chronic heart failure showing broad-spectrum anti-inflammatory approaches

L Gullestad, P Aukrust - The American journal of cardiology, 2005 - Elsevier
Accumulating evidence indicates that inflammatory mediators are important in the
pathogenesis of chronic heart failure (CHF), contributing to cardiac remodeling and …

The enigma of anti-inflammatory therapy for the management of heart failure

MN Sack - Cardiovascular Research, 2020 - academic.oup.com
The role of inflammation in heart failure was initially proposed as a mechanism driving
cardiac cachexia almost 30 years ago. Since then levels of inflammatory cytokines including …

Tumour necrosis factor-α and the failing heart: pathophysiology and therapeutic implications

S von Haehling, EA Jankowska, SD Anker - Basic Research in Cardiology, 2004 - Springer
■ Abstract Immune activation plays a significant role in the development and progression of
chronic heart failure (CHF). Indeed, pro-inflammatory cytokines, especially tumour necrosis …

How can we cure a heart “in flame”? A translational view on inflammation in heart failure

U Hofmann, S Frantz - Basic research in cardiology, 2013 - Springer
The prevalence of chronic heart failure is still increasing making it a major health issue in the
21st century. Tremendous evidence has emerged over the past decades that heart failure is …

Inflammatory cytokines in heart failure: mediators and markers

L Gullestad, T Ueland, LE Vinge, A Finsen, A Yndestad… - Cardiology, 2012 - karger.com
Evidence from both experimental and clinical trials indicates that inflammatory mediators are
of importance in the pathogenesis of chronic heart failure (HF) contributing to cardiac …