Melatonin and minocycline for combinatorial therapy to improve functional and histopathological deficits following traumatic brain injury

ML Kelso, NN Scheff, SW Scheff, JR Pauly - Neuroscience letters, 2011 - Elsevier
The biochemical sequelae that follow traumatic brain injury (TBI) are numerous and affect
many different brain functions at different points of time as the secondary cascades progress …

Targeting different pathophysiological events after traumatic brain injury in mice: Role of melatonin and memantine

T Kelestemur, B Yulug, AB Caglayan, MC Beker… - Neuroscience …, 2016 - Elsevier
The tissue damage that emerges during traumatic brain injury (TBI) is a consequence of a
variety of pathophysiological events, including free radical generation and over-activation of …

Melatonin as a potential regulator of oxidative stress, and neuroinflammation: mechanisms and implications for the management of brain injury-induced …

M Ikram, HY Park, T Ali, MO Kim - Journal of Inflammation …, 2021 - Taylor & Francis
This review covers the preclinical and clinical literature supporting the role of melatonin in
the management of brain injury-induced oxidative stress, neuroinflammation, and …

Melatonin attenuates repeated mild traumatic brain injury-induced cognitive deficits by inhibiting astrocyte reactivation

R Cao, L Li, W Zhang, J Lu, Y Wang, Q Chen… - Biochemical and …, 2021 - Elsevier
Melatonin has been well documented for its neuroprotective role through inhibiting oxidative
stress against traumatic brain injury (TBI). However, the specific role of melatonin and the …

Transient neuroprotection by minocycline following traumatic brain injury is associated with attenuated microglial activation but no changes in cell apoptosis or …

N Bye, MD Habgood, JK Callaway, N Malakooti… - Experimental …, 2007 - Elsevier
Cerebral inflammation and apoptotic cell death are two processes implicated in the
progressive tissue damage that occurs following traumatic brain injury (TBI), and strategies …

Melatonin‐induced neuroprotection after closed head injury is associated with increased brain antioxidants and attenuated late‐phase activation of NF‐κB and AP‐1

SM Beni, R Kohen, RJ Reiter, DX Tan… - The FASEB …, 2004 - Wiley Online Library
Traumatic brain injury (TBI) is followed by massive production of reactive oxygen species
(ROS), which mediate secondary cellular damage. Low molecular weight antioxidants …

Therapeutic potential of melatonin in traumatic central nervous system injury

S Samantaray, A Das, NP Thakore… - Journal of pineal …, 2009 - Wiley Online Library
A vast literature extolling the benefits of melatonin has accumulated during the past four
decades. Melatonin was previously considered of importance to seasonal reproduction and …

Does melatonin protect or treat brain damage from traumatic oxidative stress?

M Kerman, B Cirak, MF Ozguner, A Dagtekin… - Experimental brain …, 2005 - Springer
A variety of experimental studies have demonstrated the neuroprotective effects of
melatonin, based on its antioxidant activity. In a prospective randomized study, the effects of …

Melatonin ameliorates neurologic damage and neurophysiologic deficits in experimental models of stroke

RJ Reiter, RM Sainz… - Annals of the New …, 2003 - Wiley Online Library
This review summarizes the numerous reports that have documented the neuroprotective
actions of melatonin in experimental models of ischemia/reperfusion injury (stroke). In these …

Endogenous melatonin increases in cerebrospinal fluid of patients after severe traumatic brain injury and correlates with oxidative stress and metabolic disarray

MA Seifman, AA Adamides… - Journal of Cerebral …, 2008 - journals.sagepub.com
Oxidative stress plays a significant role in secondary damage after severe traumatic brain
injury (TBI); and melatonin exhibits both direct and indirect antioxidant effects. Melatonin …