Observations that hypophysectomized men demonstrate predictable azoospermia have led
to attempts to suppress gonadotropin secretion with drugs for contraceptive purposes …

Chronic treatment with agonist analogs of GnRH results in reversible oligospermia i man,
but leads to impotence and decreased libido due to a concomitant fall in serum testosterone …

Superactive analogues of gonadotrophin releasing hormone and testosterone, when
administered together, synergistically inhibit gonadotrophin secretion and spermatogenesis …

GnRH antagonists plus testosterone (T) suppress LH and FSH levels and inhibit
spermatogenesis to azoospermia or severe oligozoospermia. High-dose T treatment alone …

GnRH analogues are classified as either agonists or antagonists based on their acute
response. The agonists were initially developed as therapeutic agents to stimulate LH and …

GnRH antagonists suppress pituitary and gonadal function by competing with endogenous
GnRH for binding to receptors on pituitary gonadotrophs. We studied the effects of GnRH …

Although hormonal regimens provide effective, reversible contraception for women, no
effective hormonal contraceptive regimen has yet been developed for men. Testosterone …

The effects of a combined GnRH antagonist and testosterone (T) replacement regimen on
gonadotropins and spermatogenesis were examined to assess its potential as a male …

Efforts to develop a hormonal contraceptive regimen for men have focused on administration
of testosterone (T), alone or together with other agents. Previous regimens have successfully …

Constant infusion of GnRH agonist (GnRH-A) leads to far greater suppression of
spermatogenesis and gonadotropins in the monkey than its intermittent administration. We …