Cerebral inflammation and apoptotic cell death are two processes implicated in the
progressive tissue damage that occurs following traumatic brain injury (TBI), and strategies …

Traumatic brain injury (TBI) causes a wide spectrum of consequences, such as microglial
activation, cerebral inflammation, and focal and diffuse brain injury, as well as functional …

Elevated microglial/macrophage-associated biomarkers in the cerebrospinal fluid of infant
victims of abusive head trauma (AHT) suggest that these cells play a role in the …

Survivors of a traumatic brain injury can deteriorate years later, developing brain atrophy
and dementia. Traumatic brain injury triggers chronic microglial activation, but it is unclear …

OBJECTIVE Caspase-1 plays an important functional role mediating neuronal cell death
and dysfunction after experimental traumatic brain injury (TBI) in mice. Minocycline, a …

Background Minocycline, a second-generation tetracycline with anti-inflammatory and anti-
apoptotic properties, has been shown to promote therapeutic benefits in experimental …

One of the severe complications following traumatic brain injury (TBI) is cerebral edema and
its effective treatment is of great interest to prevent further brain damage. This study …

Mild traumatic brain injury afflicts over 2 million people annually and little can be done for
the underlying injury. The Food and Drug Administration-approved drugs Minocycline plus N …

Traumatic brain injury (TBI) differs in severity from severe to mild. This study examined
whether a combination of the drugs minocycline (MINO) plus N-acetylcysteine (NAC) …

Considering that several pathways leading to cell death are activated in cerebral ischemia,
we tested in mouse models of transient and permanent ischemia a drug cocktail aiming at …