Mineral oil saturated hydrocarbons (MOSH) in female Fischer 344 rats; accumulation of wax components; implications for risk assessment

L Barp, M Biedermann, K Grob, F Blas-Y-Estrada… - Science of the Total …, 2017 - Elsevier
Female Fischer 344 rats were exposed to three MOSH mixtures: oils largely below and
above C 25 (S-C25 and L-C25) and a 1: 1 mixture of L-C25 with a wax; doses of 400, 1000 …

Toxic effects of mineral oil saturated hydrocarbons (MOSH) and relation to accumulation in rat liver

UC Nygaard, Å Vege, T Rognum, K Grob… - Food and Chemical …, 2019 - Elsevier
Humans are daily exposed to mineral oil saturated hydrocarbons (MOSH) from the diet. We
exposed female Fischer 344 rats to a broad mixture and sub-fractions of MOSH. Chemical …

Accumulation of mineral oil saturated hydrocarbons (MOSH) in female Fischer 344 rats: comparison with human data and consequences for risk assessment

L Barp, M Biedermann, K Grob, F Blas-Y-Estrada… - Science of the Total …, 2017 - Elsevier
Female Fischer 344 rats were orally exposed to a mixture of mineral oil saturated
hydrocarbons (MOSH) of broad molecular mass range at doses of 40, 400 and 4000 mg/kg …

Update of the risk assessment of mineral oil hydrocarbons in food

EFSA Panel on Contaminants in the Food Chain … - EFSA …, 2023 - Wiley Online Library
Mineral oil hydrocarbons (MOH) are composed of saturated hydrocarbons (MOSH) and
aromatic hydrocarbons (MOAH). Due to the complexity of the MOH composition, their …

A study of the toxicity of five mineral hydrocarbon waxes and oils in the F344 rat, with histological examination and tissue-specific chemical characterisation of …

MJ Scotter, L Castle, RC Massey, PG Brantom… - Food and chemical …, 2003 - Elsevier
Five food-grade mineral hydrocarbon (MHC) materials; a low melting point wax (LMPW), a
synthetic wax (C80W) and three white oils (N15H, N70H and P70H) were administered …

Bioaccumulation and toxicity of mineral oil hydrocarbons in rats‐specificity of different subclasses of a broad mixture relevant for human dietary exposures

JP Cravedi, K Grob, UC Nygaard… - EFSA supporting …, 2017 - Wiley Online Library
The purpose of this study was to investigate the fate and effects of mineral oil saturated
hydrocarbons (MOSH) in female Fischer 344 rats. Animals were fed control diet or diet …

Mineral oil in human tissues, Part I: Concentrations and molecular mass distributions

L Barp, C Kornauth, T Wuerger, M Rudas… - Food and Chemical …, 2014 - Elsevier
Abstract Of 37 subjects aged 25–91 y (mean 67 y), mineral oil hydrocarbons were measured
in subcutaneous abdominal fat tissue, mesenteric lymph nodes (MLN), spleen, liver and …

[HTML][HTML] GTL synthetic paraffin oil shows low liver and tissue retention compared to mineral oil

JC Carrillo, H Shen, F Momin, O Kral… - Food and Chemical …, 2022 - Elsevier
Oral exposure to mineral oil may result in a narrow fraction of mineral oil saturated
hydrocarbon (MOSH) being retained in tissues. Excess of MOSH hepatic retention may lead …

Comparative toxicokinetics of low-viscosity mineral oil in Fischer 344 rats, Sprague–Dawley rats, and humans–Implications for an Acceptable Daily Intake (ADI)

PJ Boogaard, KO Goyak, RW Biles… - Regulatory Toxicology …, 2012 - Elsevier
Oral repeated-dose studies with low-viscosity mineral oils showed distinct species and strain
differences, which are hypothesized to be due to differences in bioavailability, with Fischer …

Relevance of animal studies in the toxicological assessment of oil and wax hydrocarbons. Solving the puzzle for a new outlook in risk assessment

JC Carrillo, D Danneels, J Woldhuis - Critical Reviews in …, 2021 - Taylor & Francis
Paraffin waxes and white mineral oils are distinct petroleum products separated from a
common feedstock by crystallization, where only n-alkanes, iso-and cyclo-alkanes with a …