The goal of this study was to evaluate the potential involvement of melatonin in the activation
of the nuclear factor erythroid 2-related factor 2 and antioxidant-responsive element (Nrf2 …

Melatonin has beneficial effects against early brain injury (EBI) by modulating cerebral
oxidative stress after experimental subarachnoid hemorrhage (SAH); however, few …

Traumatic brain injury (TBI) is a principal cause of death and disability worldwide. Melatonin,
a hormone made by the pineal gland, is known to have anti-inflammatory and antioxidant …

Traumatic brain injury (TBI) is followed by massive production of reactive oxygen species
(ROS), which mediate secondary cellular damage. Low molecular weight antioxidants …

Ferroptosis is a novel form of cell death that plays a critical role in the pathological and
physiological processes of early brain injury following subarachnoid hemorrhage …

This review covers the preclinical and clinical literature supporting the role of melatonin in
the management of brain injury-induced oxidative stress, neuroinflammation, and …

Melatonin (Mel) has neuroprotective effects; however, its roles in hypoxic-ischemic brain
damage (HIBD) and the underlying mechanisms remain unknown. We aimed to explore its …

Although traumatic brain injury (TBI) is a common cause of death and disability worldwide,
there is currently a lack of effective therapeutic drugs and targets. To reveal the complex …

Background: Spinal cord injury (SCI) is a central nervous system (CNS) trauma involving
inflammation and oxidative stress, which play important roles in this trauma's pathogenesis …

Luteolin has recently been proven to exert neuroprotection in a variety of neurological
diseases; however, its roles and the underlying mechanisms in traumatic brain injury are not …