Phortress is an anticancer prodrug, which has active metabolite (5F-203) being potent
agonist of the aryl hydrocarbon receptor (AhR). The 5F-203 switches on cytochrome P450 …

Background: Phortress produces reactive electrophilic metabolites that form DNA adducts
only in sensitive tumor cells. The authors converted the 2-phenylbenzothiazole nucleus in …

The present study aimed to design and synthesize a series of phenyl-isoxazole-
carboxamide derivatives and investigate their antitumor and antioxidant activities. The in …

This study deals with design and synthesis of novel benzofuran–pyrazole hybrids as
anticancer agents. Eight compounds were chosen by National Cancer Institute (NCI), USA to …

Abstract New benzoxazole derivatives containing 1, 3, 4-oxadiazole, 1, 2, 4-triazole or
triazolothiadiazine rings were synthesized and screened for their in vitro antiproliferative …

Synthesis of bioactive heterocyclic compounds having effective biological activity is an
essential research area for wide-ranging applications. In this study, a conventional …

A new series of benzothiazole has been synthesized as cytotoxic agents. The new
derivatives were tested for their cytotoxic activity toward the human breast cancer MCF‐7 …

Abstract A series of novel 4, 5‐diphenyloxazol‐1, 2, 4‐triazole derivatives (6 a–6 l) were
synthesized and screened for anticancer activity against the prostate lung cancer cell lines …

In an aim at developing new antiproliferative agents, new series of benzothiazole/
benzoxazole and/or benzimidazole substituted pyrazole derivatives 11a-c, 12a-c and 13a-c …

Background According to the report published recently by the World Health Organization,
the number of cancer cases in the world will increase to 22 million by 2030. So the …