GnRH antagonists suppress pituitary and gonadal function by competing with endogenous
GnRH for binding to receptors on pituitary gonadotrophs. We studied the effects of GnRH …

The effects of a combined GnRH antagonist and testosterone (T) replacement regimen on
gonadotropins and spermatogenesis were examined to assess its potential as a male …

Constant infusion of GnRH agonist (GnRH-A) leads to far greater suppression of
spermatogenesis and gonadotropins in the monkey than its intermittent administration. We …

GnRH antagonists plus testosterone (T) suppress LH and FSH levels and inhibit
spermatogenesis to azoospermia or severe oligozoospermia. High-dose T treatment alone …

Chronic treatment with agonist analogs of GnRH results in reversible oligospermia i man,
but leads to impotence and decreased libido due to a concomitant fall in serum testosterone …

Although hormonal regimens provide effective, reversible contraception for women, no
effective hormonal contraceptive regimen has yet been developed for men. Testosterone …

Efforts to develop a hormonal contraceptive regimen for men have focused on administration
of testosterone (T), alone or together with other agents. Previous regimens have successfully …

Superactive analogues of gonadotrophin releasing hormone and testosterone, when
administered together, synergistically inhibit gonadotrophin secretion and spermatogenesis …

The GnRH antagonist cetrorelix effectively suppresses serum LH, FSH, and testosterone (T)
in normal men without major side-effects. However, as with other available GnRH …

Antagonist analogues of gonadotropin-releasing hormone (GnRH-A) alone inhibit
spermatogenesis in experimental animals, but concomitant decline in serum testosterone …