One of the severe complications following traumatic brain injury (TBI) is cerebral edema and
its effective treatment is of great interest to prevent further brain damage. This study …

Evidence suggests that microglia activation contributes to brain injury after intracerebral
hemorrhage (ICH). The present study aimed to determine if minocycline, an inhibitor of …

Cerebral inflammation and apoptotic cell death are two processes implicated in the
progressive tissue damage that occurs following traumatic brain injury (TBI), and strategies …

Persistent inflammation, mediated in part by increases in cytokines, is a hallmark of
traumatlc brain injury (TBI). Minocycline has been shown to inhibit post-TBI …

The neuroprotective effects of minocycline–which is broadly protective in neurologic-disease
models featuring cell death and is being evaluated in clinical trials–were investigated both in …

Memory deficit is the most visible symptom of cerebral ischemia that is associated with loss
of pyramidal cells in CA1 region of the hippocampus. Oxidative stress and inflammation may …

Intracerebral hemorrhage (ICH) results from rupture of a blood vessel in the brain. After ICH,
the blood–brain barrier (BBB) surrounding the hematoma is disrupted, leading to cerebral …

Cerebral ischemia leads to memory impairment that is associated with loss of hippocampal
CA1 pyramidal neurons. Neuroinflammation and oxidative stress may be implicated in the …

Clinical trials of therapeutics for traumatic brain injury (TBI) demonstrating preclinical efficacy
for TBI have failed to replicate these results in humans, in part due to the absence of …

Study design. A prospective, randomized experimental research. Objective. To evaluate the
short-and long-term neuroprotective effects of minocycline on the secondary injury process …