Transfer RNA (tRNA) gene content is a differentiating feature of genomes that contributes to
the efficiency of the translational apparatus, but the principles shaping tRNA gene copy …

From 50 genomes of the three domains of life (7 eukarya, 13 archaea, and 30 bacteria), we
extracted, analyzed, and compared over 4,000 sequences corresponding to cytoplasmic …

Codon usage and tRNA abundance are critical parameters for gene synthesis. However, the
forces determining codon usage bias within genomes and between organisms, as well as …

Background The speed of translation elongation is primarily determined by the abundance
of tRNAs. Thus, the codon usage influences the rate with which individual mRNAs are …

The typical number of tRNA genes in bacterial genomes is around 50, but this number varies
from under 30 to over 120. We argue that tRNA gene copy numbers evolve in response to …

ABSTRACT tRNAs play a critical role in mRNA decoding, and posttranscriptional
modifications within tRNAs drive decoding efficiency and accuracy. The types and positions …

A commonly stated cause of unequal uses of synonymous codons is their differential
translational accuracies. A key prediction of this long-standing translational accuracy …

The selection-mutation-drift theory of codon usage plays a major role in the theory of
molecular evolution by explaining the co-evolution of codon usage bias and tRNA content in …

The degree to which codon usage can be explained by tRNA abundance in bacterial
species is often inadequate, partly because differential tRNA abundance is often …

Translation elongation is an accurate and rapid process, dependent upon efficient
juxtaposition of tRNAs in the ribosomal A-and P-sites. Here, we sought evidence of A-and P …