Effect of fiber length on carbon nanotube-induced fibrogenesis

A Manke, S Luanpitpong, C Dong, L Wang… - International journal of …, 2014 - mdpi.com
Given their extremely small size and light weight, carbon nanotubes (CNTs) can be readily
inhaled by human lungs resulting in increased rates of pulmonary disorders, particularly …

Mechanisms of carbon nanotube‐induced pulmonary fibrosis: a physicochemical characteristic perspective

KS Duke, JC Bonner - Wiley Interdisciplinary Reviews …, 2018 - Wiley Online Library
Carbon nanotubes (CNTs) are engineered nanomaterials (ENMs) with numerous beneficial
applications. However, they could pose a risk to human health from occupational or …

Pulmonary toxicity and fibrogenic response of carbon nanotubes

A Manke, L Wang, Y Rojanasakul - Toxicology mechanisms and …, 2013 - Taylor & Francis
Carbon nanotubes (CNTs) have been a subject of intensive research for a wide range of
applications. However, because of their extremely small size and light weight, CNTs are …

Assessment of pulmonary fibrogenic potential of multiwalled carbon nanotubes in human lung cells

A Mishra, Y Rojanasakul, BT Chen… - Journal of …, 2012 - Wiley Online Library
Multiwalled carbon nanotubes have been shown to possess unusual fibrogenic activity in
vivo and are currently the focus of intense toxicological investigations. This study further …

Identification of TGF-β receptor-1 as a key regulator of carbon nanotube-induced fibrogenesis

A Mishra, TA Stueckle, RR Mercer… - … of Physiology-Lung …, 2015 - journals.physiology.org
Carbon nanotubes (CNTs) induce rapid interstitial lung fibrosis, but the underlying
mechanisms are unclear. Previous studies indicated that the ability of CNTs to penetrate …

Mechanisms of lung fibrosis induced by carbon nanotubes: towards an Adverse Outcome Pathway (AOP)

G Vietti, D Lison, S van den Brule - Particle and fibre toxicology, 2015 - Springer
Several experimental studies have shown that carbon nanotubes (CNT) can induce
respiratory effects, including lung fibrosis. The cellular and molecular events through which …

Substrate stiffness-dependent carbon nanotube-induced lung fibrogenesis

K Wang, L Shi, W Linthicum, K Man, X He, Q Wen… - Nano …, 2019 - ACS Publications
Most living tissues exhibit the specific stiffness, which has been known to have profound
influence on cell behaviors, yet how the stiffness affects cellular responses to engineered …

Dispersal state of multiwalled carbon nanotubes elicits profibrogenic cellular responses that correlate with fibrogenesis biomarkers and fibrosis in the murine lung

X Wang, T Xia, S Addo Ntim, Z Ji, S Lin, H Meng… - ACS …, 2011 - ACS Publications
We developed a dispersal method for multiwalled carbon nanotubes (MWCNTs) that allows
quantitative assessment of dispersion on profibrogenic responses in tissue culture cells and …

Direct fibrogenic effects of dispersed single-walled carbon nanotubes on human lung fibroblasts

L Wang, RR Mercer, Y Rojanasakul, A Qiu… - Journal of Toxicology …, 2010 - Taylor & Francis
Nanomaterials, including single-walled carbon nanotubes (SWCNT), are being developed
for a variety of commercial products. However, adverse health effects attributed to these new …

Microenvironmental alterations in carbon nanotube-induced lung inflammation and fibrosis

J Dong - Frontiers in Cell and Developmental Biology, 2020 - frontiersin.org
Carbon nanotube (CNT)-induced pulmonary inflammation and fibrosis have been
intensively observed and characterized in numerous animal studies in the past decade …