[PDF][PDF] A theoretical exploration of birhythmicity in the p53-Mdm2 network
WAJM Chaves–Jean, L Gouzé - 2010 - core.ac.uk
Experimental observations performed in the p53-Mdm2 network, one of the key protein
module involved in the control of proliferation of abnormal cells in mammals, revealed the …
module involved in the control of proliferation of abnormal cells in mammals, revealed the …
A theoretical exploration of birhythmicity in the p53-Mdm2 network
Experimental observations performed in the p53-Mdm2 network, one of the key protein
modules involved in the control of proliferation of abnormal cells in mammals, revealed the …
modules involved in the control of proliferation of abnormal cells in mammals, revealed the …
Mechanisms for coexistence of two limit cycles in a biochemical model1
Recently, a differential model of the p53-Mdm2 biochemical network which shows
birhythmicity has been proposed to reproduce the two experimentally observed frequencies …
birhythmicity has been proposed to reproduce the two experimentally observed frequencies …
Spatio-temporal modelling of the p53–mdm2 oscillatory system
KE Gordon, IMM Van Leeuwen, S Lain… - … Modelling of Natural …, 2009 - cambridge.org
In this paper we investigate the role of spatial effects in determining the dynamics of a
subclass of signalling pathways characterised by their ability to demonstrate oscillatory …
subclass of signalling pathways characterised by their ability to demonstrate oscillatory …
From structure to dynamics: Frequency tuning in the p53-Mdm2 network. II: Differential and stochastic approaches
In Part I of this work, we carried out a logical analysis of a simple model describing the
interplay between protein p53, its main negative regulator Mdm2 and DNA damage, and …
interplay between protein p53, its main negative regulator Mdm2 and DNA damage, and …
Oscillations, variability and frequency tuning in the p53-Mdm2 network
We investigate the dynamical properties of a simple four-variable model describing the
interactions between the tumour suppressor protein p53, its main negative regulator Mdm2 …
interactions between the tumour suppressor protein p53, its main negative regulator Mdm2 …
From structure to dynamics: frequency tuning in the p53–mdm2 network: I. logical approach
We investigate the dynamical properties of a simple four-variable model describing the
interactions between the tumour suppressor protein p53, its main negative regulator Mdm2 …
interactions between the tumour suppressor protein p53, its main negative regulator Mdm2 …
Oscillatory expression and variability in p53 regulatory network
B Liu, S Yan, Q Wang, S Liu - Physica D: Nonlinear Phenomena, 2011 - Elsevier
The effect of delay, nonlinearity and noise on oscillatory motion is of permanent interest for
theoretical and experimental research. Here we explore a negative feedback loop between …
theoretical and experimental research. Here we explore a negative feedback loop between …
Influence of parameter values on the oscillation sensitivities of two p53–Mdm2 models
Biomolecular networks that present oscillatory behavior are ubiquitous in nature. While
some design principles for robust oscillations have been identified, it is not well understood …
some design principles for robust oscillations have been identified, it is not well understood …
Piecewise parametric chaotic model of p53 network based on the identified unifying framework of divergent p53 dynamics
G Demirkıran - Chaos, Solitons & Fractals, 2022 - Elsevier
Being the core of the large p53 protein (cancer) network, the ATM-p53-Wip1 sub-network is
known to confer monostable oscillations and fixed levels of p53 to the p53 network. Using a …
known to confer monostable oscillations and fixed levels of p53 to the p53 network. Using a …