[HTML][HTML] A nicotinic hypothesis for Covid-19 with preventive and therapeutic implications

JP Changeux, Z Amoura… - Comptes …, 2020 - comptes-rendus.academie-sciences …
SARS-CoV-2 epidemics raises a considerable issue of public health at the planetary scale.
There is a pressing urgency to find treatments based upon currently available scientific …

Nicotine and the nicotinic cholinergic system in COVID‐19

Y Tizabi, B Getachew, RL Copeland… - The FEBS …, 2020 - Wiley Online Library
There is an urgent need to address the devastating pandemic, COVID‐19, caused by SARS‐
CoV‐2. The efforts to understand the details of this disease in hope of providing effective …

COVID-19 and the nicotinic cholinergic system

K Farsalinos, A Angelopoulou… - European …, 2020 - Eur Respiratory Soc
We have read with great interest the paper by Leung et al.[1] published in the European
Respiratory Journal, the correspondence by Russo et al.[2], and also the subsequent …

[HTML][HTML] Nicotine and SARS-CoV-2: COVID-19 may be a disease of the nicotinic cholinergic system

K Farsalinos, R Niaura, J Le Houezec… - Toxicology …, 2020 - ncbi.nlm.nih.gov
As of 20 April, almost 1.7 million people globally have been diagnosed with Corona Virus
Disease 2019 (COVID-19), a pandemic that has evolved from the emergence of a new …

Beyond smoking cessation: investigating medicinal nicotine to prevent and treat COVID-19

HA Tindle, PA Newhouse… - Nicotine and Tobacco …, 2020 - academic.oup.com
In the absence of treatment or a vaccine, the SARS-CoV-2 pandemic challenges the medical
community to identify novel containment strategies. Changeux et al. 1 have proposed the …

[HTML][HTML] Nicotinic cholinergic system and COVID-19: In silico evaluation of nicotinic acetylcholine receptor agonists as potential therapeutic interventions

N Alexandris, G Lagoumintzis, CT Chasapis… - Toxicology reports, 2021 - Elsevier
SARS-CoV-2 infection was announced as a pandemic in March 2020. Since then, several
scientists have focused on the low prevalence of smokers among hospitalized COVID-19 …

Nicotinic cholinergic system and COVID-19: in silico identification of an interaction between SARS-CoV-2 and nicotinic receptors with potential therapeutic targeting …

K Farsalinos, E Eliopoulos, DD Leonidas… - International journal of …, 2020 - mdpi.com
While SARS-CoV-2 uses angiotensin converting enzyme 2 (ACE2) as the receptor for cell
entry, it is important to examine other potential interactions between the virus and other cell …

How nicotine can inhibit cytokine storm in the lungs and prevent or lessen the severity of COVID-19 infection?

M Kloc, RM Ghobrial, JZ Kubiak - Immunology letters, 2020 - Elsevier
Statistical surveys of COVID-19 patients indicate, against all common logic, that people who
smoke are less prone to the infection and/or exhibit less severe respiratory symptoms than …

Is nicotine exposure linked to cardiopulmonary vulnerability to COVID‐19 in the general population?

JL Olds, N Kabbani - The FEBS journal, 2020 - Wiley Online Library
The recent emergence of COVID‐19 has resulted in a worldwide crisis, with large
populations locked down and transportation links severed. While approximately 80% of …

Cholinergic dysfunction in COVID-19: frantic search and hoping for the best

EH Nadwa, HM Al-Kuraishy, AI Al-Gareeb… - Naunyn-Schmiedeberg's …, 2023 - Springer
A novel coronavirus known as severe acute respiratory syndrome coronavirus type 2 (SARS-
CoV-2) is a potential cause of acute respiratory infection called coronavirus disease 2019 …