Prostaglandins are important mediators of bone repair, and cyclooxygenases are required
for prostaglandin production. Data from animal studies suggest that both non-specific and …

Cyclooxygenases (COX-1 and COX-2) catalyze the conversion of arachidonic acid to
prostaglandins (PGs). PGs play a significant role in bone metabolism in health and disease …

NON-STEROIDAL ANTI-INFLAMMATORY drugs (NSAIDs) are among the most commonly
prescribed drugs worldwide. Indicated in the treatment of several forms of arthritis, menstrual …

Cyclooxygenase (COX) catalyzes the initial step of arachidonic acid metabolism and
prostaglandin production. COX activity has been found to be associated with 2 distinct …

Background: Cyclooxygenase-2-specific anti-inflammatory drugs (coxibs) and nonspecific
nonsteroidal anti-inflammatory drugs have been shown to inhibit experimental fracture …

Prostaglandins (PGs) are released as part of the inflammatory response. They are
synthesised from arachidonic acid by the cyclooxygenase enzymes, COX-1 and-2. NSAIDS …

In the study reported here, we determined the effects on bone healing of rofecoxib, one of
the selective cyclooxygenase-2 (Cox-2) inhibitors that has been used for postsurgical …

Nearly 30 years ago, cyclooxygenase (COX) was identified as an enzyme that initiates the
biotransformation of arachidonic acid to prostanoids. It is now known that COX exists as two …

Background: The effects of cyclooxygenase (COX) inhibition on fracture healing are
insufficiently documented, and the aim of this study was to evaluate the effects of nonspecific …

The physiological mechanisms of fracture healing have been the topic of active investigation
for many years. At the present time ample data exist on the histological, mechanical and …