Objective Isolated pancreatic islets are valuable resources for a wide range of research,
including cell replacement studies and cell-based platforms for diabetes drug discovery and …

Background & objectives Isolation of functional pancreatic islets for diabetes research and
clinical islet transplantation stands as a big challenge despite the advancements in the field …

Isolating a large quantity of high-quality human islets is a prerequisite for diabetes research.
Human islets are typically isolated from the pancreases of brain-dead donors, making …

Successful islet isolation is crucial for islet transplantation and cell treatment for type 1
diabetes. Current isolation methods are able to obtain 500-1,000 islets per rat, which results …

Type 2 diabetes mellitus (T2D) affects 463 million individuals worldwide. β-cell dysfunction
and relatively inadequate β-cell mass has been implicated in the pathogenesis of T2D …

Yields and function of isolated islets vary considerably in spite of the introduction of new or
improved methods for isolation. In most studies, these variations have been attributed to …

Objectives The canine model has been used extensively to improve the human pancreatic
islet isolation technique. At the functional level, dog islets show high similarity to human …

Successful islet isolation is the key to islet transplantation in diabetic patients. However, islet
isolation is a technically complex and time-consuming manual process. Optimizing the islet …

Background Transplantation of the human pancreatic islets is a promising approach for
specific types of diabetes to improve glycemic control. Although effective, there are several …

Many procedures have been described for rat pancreatic islet isolation. Several factors
contribute to the pancreatic islet isolation outcome. One of the main problems in islet …