A cytoplasmic complex mediates specific mRNA recognition and localization in yeast

M Müller, RG Heym, A Mayer, K Kramer, M Schmid… - PLoS …, 2011 - journals.plos.org
In eukaryotes, hundreds of mRNAs are localized by specialized transport complexes. For
localization, transcripts are recognized by RNA-binding proteins and incorporated into motor …

Formation of She2p tetramers is required for mRNA binding, mRNP assembly, and localization

M Müller, K Richter, A Heuck, E Kremmer, J Buchner… - Rna, 2009 - rnajournal.cshlp.org
In eukaryotic cells, dozens to hundreds of different mRNAs are localized by specialized
motor-dependent transport complexes. One of the best-studied examples for directional …

Of social molecules: The interactive assembly of ASH1 mRNA-transport complexes in yeast

A Niedner, FT Edelmann, D Niessing - RNA biology, 2014 - Taylor & Francis
Asymmetric, motor-protein dependent transport of mRNAs and subsequent localized
translation is an important mechanism of gene regulation. Due to the high complexity of such …

Directional mRNA transport in eukaryotes: lessons from yeast

M Müller, A Heuck, D Niessing - Cellular and molecular life sciences, 2007 - Springer
In eukaryotes, developmental processes and cell differentiation, as well as basic cellular
functions require the propagation of information in an asymmetric manner. Localization of …

In vitro reconstitution of an mRNA-transport complex reveals mechanisms of assembly and motor activation

RG Heym, D Zimmermann, FT Edelmann… - Journal of Cell …, 2013 - rupress.org
The assembly and composition of ribonucleic acid (RNA)–transporting particles for
asymmetric messenger RNA (mRNA) localization is not well understood. During mitosis of …

Molecular architecture and dynamics of ASH1 mRNA recognition by its mRNA-transport complex

FT Edelmann, A Schlundt, RG Heym… - Nature structural & …, 2017 - nature.com
Abstract mRNA localization is an essential mechanism of gene regulation and is required for
processes such as stem-cell division, embryogenesis and neuronal plasticity. It is not known …

Unbiased selection of localization elements reveals cis-acting determinants of mRNA bud localization in Saccharomyces cerevisiae

A Jambhekar, K McDermott, K Sorber… - Proceedings of the …, 2005 - National Acad Sciences
Cytoplasmic mRNA localization is a mechanism used by many organisms to generate
asymmetry and sequester protein activity. In the yeast Saccharomyces cerevisiae, mRNA …

[HTML][HTML] She2p is a novel RNA binding protein with a basic helical hairpin motif

D Niessing, S Hüttelmaier, D Zenklusen, RH Singer… - Cell, 2004 - cell.com
Selective transport of mRNAs in ribonucleoprotein particles (mRNP) ensures asymmetric
distribution of information within and among eukaryotic cells. Actin-dependent transport of …

Localization and anchoring of mRNA in budding yeast

DL Beach, ED Salmon, K Bloom - Current Biology, 1999 - cell.com
Background: Eukaryotic cells localize selected mRNAs to a region of the cell as a means to
sequester proteins. Signals within the 3′ untranslated region (3′ UTR) facilitate mRNA …

Translocation of mRNAs by molecular motors: think complex?

SL Bullock - Seminars in cell & developmental biology, 2007 - Elsevier
In recent years, closer inspection of the dynamics of cytoplasmic mRNA transport processes
has shed new light on the mechanisms by which transcripts are recognized by motor …