The molecular mechanisms underlying the pathophysiology of bone destruction still remain
poorly understood. We have found that hydrogen peroxide (H 2 O 2), a reactive oxygen …

Reactive oxygen species such as superoxide and hydrogen peroxide have been implicated
as regulatory factors in the control of osteoclastic bone resorption. While superoxide radicals …

The mechanisms by which bone resorbing osteoclasts form and are activated by hormones
are poorly understood. We show here that the generation of oxygen-derived free radicals in …

Abstract Hydrogen peroxide (H 2 O 2), superoxide anion radical (O 2− radical dot), and other
forms of reactive oxygen species (ROS) are produced by the vast majority of mammalian …

Hypoxia is known to act as a general stimulator of cells derived from marrow precursors. We
investigated the effect of oxygen tension on the formation and function of osteoclasts, the …

Osteoclasts have been shown to produce reactive oxygen intermediates (ROI) and it has
been suggested that ROI are involved in the process of bone resorption. ROI have also been …

We have shown that superoxide anion (O 2−) production by the osteoclast can be used as
an index of the osteoclast activity since the agents that inhibit and stimulate the osteoclast …

Production of superoxide radicals by osteoclasts is necessary for normal bone degradation.
White blood cell superoxide, needed for bacterial killing, is produced by activated NADPH …

Recent reports have suggested that production of superoxide or other reactive oxygen
species by activated osteoclasts may play a role in the complex process of bone resorption; …

Abstract Hydrogen peroxide (H 2 O 2), an oxidizing agent, has been widely used as a
disinfectant. Recently, because of its reactive properties, H 2 O 2 has also been used as a …