Background: Amyloid deposition in the brain is an early event in Alzheimer's disease (AD),
but a dysfunction of the blood-brain barrier or a disturbance in the metabolism of folate and …

Objective Hyperhomocysteinemia (HHcy), as an important risk factor for Alzheimer's disease
(AD), would aggravate cognitive dysfunction. This study aimed to investigate whether and to …

Background: Increased plasma total homocysteine (tHcy) is a risk factor for neurological
diseases, but the underlying pathophysiology has not been adequately explained. Methods …

Background: A moderate elevation of plasma total homocysteine (tHcy) is considered a
potential risk factor for Alzheimer's disease (AD). Methods: We have investigated the main …

Recent work on high plasma homocysteine levels in patients at risk for developing
Alzheimer's disease has led to the hypothesis that folic acid supplementation might reduce …

Background: Increased plasma homocysteine levels have been described as an
independent risk factor for Alzheimer's disease (AD), but the underlying pathophysiology is …

Disturbed homocysteine metabolism is a risk factor for Alzheimer's disease (AD) and may
contribute to the disease pathophysiology by increasing both amyloid-β (Aβ) production and …

Homocysteine (Hcy) is a risk factor for brain atrophy, cognitive impairment, and dementia.
Vitamin B12 and folate are cofactors necessary for the methylation of Hcy. However, there is …

Folic acid is believed to play a role in protection from oxidant stress. Low levels of folic acid
had been found in serum from patients with Alzheimer disease (AD). Folate concentration …

Background Recent studies suggest that vascular disease may contribute to the cause of
Alzheimer disease (AD). Since elevated plasma total homocysteine (tHcy) level is a risk …