Preclinical and clinical advances in dual‐target chimeric antigen receptor therapy for hematological malignancies

Z Guo, S Tu, S Yu, L Wu, W Pan, N Chang… - Cancer …, 2021 - Wiley Online Library
In recent years, the excellent curative effect of CD19‐specific chimeric antigen receptor
(CAR) T‐cell therapy has brought hope to patients with relapsing or refractory B‐cell …

CD19-targeted CAR T-cell therapeutics for hematologic malignancies: interpreting clinical outcomes to date

JH Park, MB Geyer, RJ Brentjens - Blood, The Journal of the …, 2016 - ashpublications.org
Adoptive transfer of T cells genetically modified to express chimeric antigen receptors
(CARs) targeting CD19 has produced impressive results in treating patients with B-cell …

Chimeric antigen receptor (CAR) T cells: lessons learned from targeting of CD19 in B-cell malignancies

KA Hay, CJ Turtle - Drugs, 2017 - Springer
Adoptive immunotherapy with chimeric antigen receptor-modified (CAR)-T cells is a rapidly
growing therapeutic approach to treating patients with refractory cancer, with over 100 …

New targets for CAR T therapy in hematologic malignancies

M Savani, O Oluwole, B Dholaria - Best practice & research Clinical …, 2021 - Elsevier
As we expand our acumen of the intricacies of hematological malignancies at a genetic and
cellular level, we have paved the way in advancing novel targeted therapeutic avenues such …

Overcoming CAR-mediated CD19 downmodulation and leukemia relapse with T lymphocytes secreting anti-CD19 T-cell Engagers

B Blanco, Á Ramírez-Fernández, C Bueno… - Cancer immunology …, 2022 - AACR
Chimeric antigen receptor (CAR)–modified T cells have revolutionized the treatment of
CD19-positive hematologic malignancies. Although anti-CD19 CAR-engineered autologous …

CAR-T cells shoot for new targets: novel approaches to boost adoptive cell therapy for B cell-derived Malignancies

K Marhelava, M Krawczyk, M Firczuk, K Fidyt - Cells, 2022 - mdpi.com
Chimeric antigen receptor (CAR)-T cell therapy is undeniably a promising tool in combating
various types of hematological malignancies. However, it is not yet optimal and a significant …

Safety and efficacy of humanized versus murinized CD19 and CD22 CAR T-cell cocktail therapy for refractory/relapsed B-cell lymphoma

L Huang, J Li, J Yang, X Zhang, M Zhang, J He… - Cells, 2022 - mdpi.com
CD19 chimeric antigen receptor T-cell (CAR-T) therapy is efficacious for refractory/relapsed
(R/R) B-cell hematological malignancies, yet relapse due to CD19 antigen escape remains …

CAR T-cell immunotherapy of B-cell malignancy: the story so far

L Halim, J Maher - Therapeutic advances in vaccines and …, 2020 - journals.sagepub.com
Chimeric antigen receptor (CAR) T-cell immunotherapy has achieved unprecedented
efficacy in the treatment of chemotherapy-resistant or refractory B-cell malignancies …

Multi targeted CAR-T cell therapies for B-cell malignancies

NN Shah, T Maatman, P Hari, B Johnson - Frontiers in oncology, 2019 - frontiersin.org
Chimeric antigen receptor (CAR) modified T cell therapy has revolutionized the treatment of
relapsed and refractory hematological malignancies. Through targeting of the CD19 antigen …

Bispecific CAR T-cells for B-cell malignancies

F Furqan, NN Shah - Expert Opinion on Biological Therapy, 2022 - Taylor & Francis
Introduction Chimeric antigen receptor (CAR)-modified T-cell therapy has revolutionized the
treatment of relapsed/refractory B-cell malignancies including acute lymphoblastic leukemia …