The symptoms of depression can be improved by agents that act by various mechanisms to
increase synaptic concentrations of monoamines. This finding led to the adoption of the …

Several classes of antidepressant drug exist, divided into three broad families, the
monoamine reuptake inhibitors, the monoamine oxidase inhibitors and the monoamine …

The monoamine hypothesis of depression predicts that the underlying pathophysiologic
basis of depression is a depletion in the levels of serotonin, norepinephrine, and/or …

The original hypothesis that brain monoamine systems have a primary direct role in
depression has been through several modifications during the past 30 years. In order to test …

The monoamine hypothesis of depression suggests that depressive symptoms can be
moderated by enhancing monoamine neurotransmission. Targeted neurotransmitters …

BACKGROUND Research on the neurobiology of depression began in earnest in the late
1950s, when converging lines of evidence pointed to the possibility of dysfunction of CNS …

Major depression is a serious disorder of enormous sociological and clinical relevance. The
discovery of antidepressant drugs in the 1950s led to the first biochemical hypothesis of …

This article reviews the role of norepinephrine (NE) and serotonin (5-HT) in depression and
the therapeutic effects of antidepressant drugs from the perspective of human …

Depression is a major illness. While its precise prevalence is unknown, some 400,000
patients are treated annually in the USA and suicide is rated as the tenth greatest cause of …

The role of the monoamines serotonin and noradrenaline in mental illnesses including
depression is well recognized. All antidepressant drugs in clinical use increase acutely the …