Background Offset analgesia is a disproportionate decrease of pain perception following a
slight decrease of noxious thermal stimulus and attenuated in patients with neuropathic …

Patients with neuropathic pain and fibromyalgia showed reduced or absent offset analgesia
(OA) response and attenuated cerebral activity in descending pain modulatory and reward …

Objectives Offset analgesia (OA) induces a brief pain inhibition and studies suggest OA
impairment in patients with chronic pain when compared to healthy subjects. Conditioned …

Offset analgesia (OA) represents a disproportionately large decrease of pain perception
after a brief, temporary increment of thermal pain stimulus and was reported attenuated in …

Interrupting a continuous noxious heat by a greater noxious heat causes rapid and
disproportionate pain reduction when the original noxious heat returns. This reduction in …

Background A noxious stimulus following a more intense stimulus often feels less painful
than continuous noxious stimulation. This effect, known as offset analgesia (OA), may be …

Abstract Background Offset Analgesia (OA) can be evoked by a three‐heat‐stimulus train
(T1‐T2‐T3), with T1 (5 s) and T3 (20 s) having the same temperature (eg 48° C) and T2 (5 s) …

A frequently used paradigm to quantify endogenous pain modulation is offset analgesia,
which is defined as a disproportionate large reduction in pain following a small decrease in …

Background Offset analgesia (OA) is a disproportionally large decrease in the pain
perception in response to a small decrease in the stimulation intensity. Traditionally, heat …

An age-related decline in endogenous pain inhibitory processes likely places older adults at
an increased risk for chronic pain. Limited research indicates that older adults may be …