Design, synthesis, anticancer activity of new amide derivatives derived from 1, 2, 3-triazole-benzofuran hybrids: An insights from molecular docking, molecular …

N Gariganti, SK Loke, E Pagadala, P Chinta… - Journal of Molecular …, 2023 - Elsevier
A new series of amide derivatives derived from 1, 2, 3-triazole-benzofuran hybrids (9a-j)
have been synthesized and their structures were confirmed by using spectroscopic …

[PDF][PDF] Synthesis, docking study, and structure activity relationship of novel anti-tumor 1, 2, 4 triazole derivatives incorporating 2-(2, 3-dimethyl aminobenzoic acid) …

H Alsaad, A Kubba, LH Tahtamouni… - Pharmacia, 2022 - pharmacia.pensoft.net
A series of 1, 2, 4 triazole derivatives (H7-12) have been synthesized by reacting an excess
of hydrazine hydrate with carbothioamide derivatives (H1-6). The final compounds (HB1 …

Design, synthesis, molecular modeling, anticancer studies, and density functional theory calculations of 4-(1, 2, 4-triazol-3-ylsulfanylmethyl)-1, 2, 3-triazole derivatives

A Al Sheikh Ali, D Khan, A Naqvi, FF Al-Blewi… - ACS …, 2020 - ACS Publications
New conjugates of substituted 1, 2, 3-triazoles linked to 1, 2, 4-triazoles were synthesized
starting from the appropriate S-propargylated 1, 2, 4-triazoles 7 and 8. Ligation of 1, 2, 4 …

Molecular docking studies, biological evaluation and synthesis of novel 3-mercapto-1, 2, 4-triazole derivatives

J Ghanaat, MA Khalilzadeh, D Zareyee - Molecular diversity, 2021 - Springer
Synthesis of bioactive heterocyclic compounds having effective biological activity is an
essential research area for wide-ranging applications. In this study, a conventional …

Rational design of 1, 2, 3-triazole hybrid structures as novel anticancer agents: synthesis, biological evaluation and molecular docking studies

A Çot, M Çeşme, S Onur, E Aksakal… - Journal of …, 2023 - Taylor & Francis
New hybrid compounds belonging to the class of 1, 4-disubstituted 1, 2, 3-triazoles were
synthesized. The structural characterization of the synthesized compounds was performed …

Design, synthesis, anticancer and antioxidant activities of amide linked 1, 4-disubstituted 1, 2, 3-triazoles

CP Kaushik, J Sangwan, R Luxmi, D Kumar… - Journal of Molecular …, 2021 - Elsevier
To explore anticancer and antioxidant agents with improved potency, we synthesized a
series of amide linked 1, 4-disubstituted 1, 2, 3-triazoles through click chemistry approach …

New 1, 2, 4‐Triazole Scaffolds as Anticancer Agents: Synthesis, Biological Evaluation and Docking Studies

NK Maddali, VKV Ivaturi… - …, 2021 - Wiley Online Library
Abstract A series of novel 4, 5‐diphenyloxazol‐1, 2, 4‐triazole derivatives (6 a–6 l) were
synthesized and screened for anticancer activity against the prostate lung cancer cell lines …

Synthesis, characterisation of new derivatives with mono ring system of 1, 2, 4-triazole scaffold and their anticancer activities

MM Slaihim, FSR Al-Suede, M Khairuddean… - Journal of Molecular …, 2019 - Elsevier
In the present study, two important starting materials and 18 new 1, 2, 4-triazole compounds
with mono ring system have been synthesized and characterized. The mono system showed …

New 1, 2, 3-triazole-containing hybrids as antitumor candidates: Design, click reaction synthesis, DFT calculations, and molecular docking study

IH El Azab, HS El-Sheshtawy, RB Bakr, NAA Elkanzi - Molecules, 2021 - mdpi.com
In an effort to improve and achieve biologically active anticancer agents, a novel series of 1,
2, 3-triazole-containing hybrids were designed and efficiently synthesized via the Cu …

Design, synthesis, biological evaluation and molecular docking studies of novel benzofuran–pyrazole derivatives as anticancer agents

SS Abd El-Karim, MM Anwar, NA Mohamed, T Nasr… - Bioorganic …, 2015 - Elsevier
This study deals with design and synthesis of novel benzofuran–pyrazole hybrids as
anticancer agents. Eight compounds were chosen by National Cancer Institute (NCI), USA to …