We hypothesized that a limitation in the endogenous formation of glycine might constrain
catch-up growth during recovery from severe childhood malnutrition. The urinary excretion of …

Urinary 5-L-oxoproline was measured in term and preterm infants from shortly after birth until
6 weeks of postnatal age to determine their ability to synthesise glycine. In term infants the …

A method for measuring 5-L-oxoproline in urine, which involves isolation by short-column
chromatography, acid hydrolysis to glutamic acid and enzymic assay of glutamic acid, was …

1. The evidence is accumulating to suggest that glycine, the simplest amino acid, is
conditionally essential in man. Benzoic acid, by conjugation with glycine to form hippuric …

l-5-oxoproline (l-5-OP) is an intermediate in glutathione synthesis, possibly limited by
cysteine availability. Urinary 5-OP excretion has been proposed as a measure of glycine …

The cellular metabolism of glutamine and proline are closely interrelated, because they can
be interconverted with glutamate and ornithine via the mitochondrial pathway involving …

At normal intakes, dietary glutamine and glutamate are metabolized by the small intestine
and essentially all glutamine within the body is synthesized de novo through the action of …

Urinary 5-L-oxoproline was measured during normal pregnancies in Southampton, England
and Kingston, Jamaica. The CV of 5-L-oxoproline excretion in urine, determined over 7 d in …

Compromised glutathione homeostasis is associated with increased morbidity in various
disease states. We evaluated the kinetics of l-5-oxoproline, an intermediate in the γ-glutamyl …

In patients with defects in the synthesis, breakdown and metabolism of glutathione (GSH),
like glutathione synthetase deficiency (GSD) and 5-oxoprolinase deficiency, urinary …