Chronic exposure to commercial glucose-based peritoneal dialysis fluids during peritoneal
dialysis induces peritoneal membrane damage leading to ultrafiltration failure. In this study …

Background Peritoneal membrane (PM) damage during peritoneal dialysis (PD) is mediated
largely by high glucose (HG)–induced pro-inflammatory and neo-angiogenic processes …

High glucose–induced PKC activation mediates TGF-β1 and fibronectin synthesis by
peritoneal mesothelial cells. Background Progressive peritoneal fibrosis, membrane …

High glucose induces MCP-1 expression partly via tyrosine kinase–AP-1 pathway in
peritoneal mesothelial cells. Background High glucose in peritoneal dialysis solutions has …

The mechanism of peritoneal fibrosis in patients on continuous ambulatory peritoneal
dialysis (CAPD) is poorly elucidated. We investigated the cellular mechanism of high …

Background Bacterial peritonitis is one of the most frequent complications in patients on
peritoneal dialysis. In the present study, we investigated effects of peritoneal dialysis fluid …

High glucose activates the p38 MAPK pathway in cultured human peritoneal mesothelial
cells. Background Peritoneal fibrosis is a serious complication in long-term continuous …

Background Bacterial peritonitis is a frequent complication in patients on peritoneal dialysis
(PD). We previously reported that PD fluid (PDF) suppressed expression of monocyte …

Background Peritoneal fibrosis is a serious complication of long-term peritoneal dialysis,
and yet the precise pathogenic mechanisms of peritoneal fibrosis remain unknown …

Introduction Chronic uremia and the exposure to dialysis solutions during peritoneal dialysis
(PD) induce peritoneal alterations. Using a long-term peritoneal exposure model, we …