Abstract tRNA‐Guanine transglycosylase (TGT) plays a key role in the post‐transcriptional
modification of tRNA. It has been linked with the pathogenicity of shigellae, the causative …

This paper describes the rational design, synthesis, and biological evaluation of a new
generation of inhibitors of the bacterial enzyme tRNA‐guanine transglycosylase (TGT) …

In a computational and structural study, we investigated a series of 4‐substituted lin‐
benzoguanines that are potent inhibitors of tRNA‐guanine transglycosylase (TGT), a …

The tRNA‐modifying enzyme tRNA–guanine transglycosylase (TGT) is essential for the
pathogenic mechanism of Shigella flexneri, the causing agent of the bacterial diarrheal …

The tRNA-modifying enzyme tRNA–guanine transglycosylase (TGT) has been recognized
as a drug target for the treatment of the foodborne illness shigellosis. The active site of TGT …

Crystallography provides structural information crucial for fragment optimization, however
several criteria must be met to screen directly on protein crystals as soakable, well …

The enzyme tRNA-guanine transglycosylase (TGT) is involved in the pathogenicity of
Shigellae. As the crystal structure of this protein is known, it is a putative target for the …

Eubacterial tRNA-guanine transglycosylase (TGT) is involved in the hyper-modification of
cognate tRNAs leading to the exchange of G34 at the wobble position in the anticodon loop …

Eubacterial tRNA-guanine transglycosylase (TGT) is involved in the hypermodification of
cognate tRNAs, leading to the exchange of G34 by preQ1 at the wobble position in the …

Shigellosis (bacillary dysentary) is a bacterial disease that results in more than one million
deaths each year.[1] Enteric infections caused by the Shigella organisms have traditionally …