To determine the incidence and extent of calcification of implanted glutaraldehyde-treated
porcine prosthetic heart valves, 82 valves explanted from 73 patients were examined for …

Calcification developed in the degenerating collagen of the cusps of three porcine xenograft
heart valves implanted in children for less than 4 years. The morphologic features and …

Sixty-seven glutaraldehyde-processed porcine bioprostheses (PBs), recovered at autopsy or
reoperation from 65 patients, were evaluated by roentgenologic and pathologic …

Calcification, the major cause of bioprosthetic heart valve failures, is a serious clinical
problem with uncertain pathogenesis. The objectives of the present study were to define the …

Bioprosthetic valve calcification is usually assessed pathologically by gross inspection,
radiographic studies, and histologic examination. Quantitation of mineral content by …

Gross, histologic and ultrastructural studies were made of 14 porcine valve bioprostheses
that were found to contain calcific deposits at the time of removal either at reoperation (13 …

The lifetime of bioprosthetic heart valves is limited by primary tissue failure and calcification
of the valve leaflets. There are indications that synthetic elastomeric materials may also be …

Both in vivo and in vitro models have been developed to study the initiation and progression
of dystrophic calcification of bioprosthetic heart valves. Circulatory in vivo models have …

The purpose of this study was to characterize the onset and progression of mineralization in
porcine bioprosthetic valves implanted in sheep and to test the hypothesis that such valves …

Human Disease The development of an ideal cardiac valve substi-tute remains a major
problem in cardiac surgery. Mechanical prosthetic valves are usually durableand …