CR16 forms a complex with N-WASP in brain and is a novel member of a conserved proline-rich actin-binding protein family

HYH Ho, R Rohatgi, L Ma… - Proceedings of the …, 2001 - National Acad Sciences
The Neuronal Wiskott–Aldrich syndrome protein (N-WASP) has emerged as a central
regulator of the actin cytoskeleton with abilities to integrate multiple upstream signal inputs …

Identification of another actin-related protein (Arp) 2/3 complex binding site in neural Wiskott-Aldrich syndrome protein (N-WASP) that complements actin …

S Suetsugu, H Miki, T Takenawa - Journal of Biological Chemistry, 2001 - ASBMB
Neural Wiskott-Aldrich syndrome protein (N-WASP) is an essential regulator of actin
cytoskeleton formation via its association with the actin-related protein (Arp) 2/3 complex. It …

Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate

R Rohatgi, HH Ho, MW Kirschner - The Journal of cell biology, 2000 - rupress.org
Neuronal Wiskott-Aldrich Syndrome protein (N-WASP) transmits signals from Cdc42 to the
nucleation of actin filaments by Arp2/3 complex. Although full-length N-WASP is a weak …

Nck and phosphatidylinositol 4, 5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway

R Rohatgi, P Nollau, HYH Ho, MW Kirschner… - Journal of Biological …, 2001 - ASBMB
The Wiskott-Aldrich syndrome protein (WASP) and its relative neural WASP (N-WASP)
regulate the nucleation of actin filaments through their interaction with the Arp2/3 complex …

A novel neural Wiskott-Aldrich syndrome protein (N-WASP) binding protein, WISH, induces Arp2/3 complex activation independent of Cdc42

M Fukuoka, S Suetsugu, H Miki, K Fukami… - The Journal of cell …, 2001 - rupress.org
We identified a novel adaptor protein that contains a Src homology (SH) 3 domain, SH3
binding proline-rich sequences, and a leucine zipper-like motif and termed this protein …

Identification of N-WASP homologs in human and rat brain

M Fukuoka, H Miki, T Takenawa - Gene, 1997 - Elsevier
We recently identified Neural Wiskott–Aldrich Syndrome Protein (N-WASP) from bovine
brain. An expression analysis using bovine cDNA revealed that N-WASP plays critical roles …

Interaction of HSP90 to N‐WASP leads to activation and protection from proteasome‐dependent degradation

SJ Park, S Suetsugu, T Takenawa - The EMBO Journal, 2005 - embopress.org
Neural Wiskott–Aldrich syndrome protein (N‐WASP) regulates reorganization of the actin
cytoskeleton through activation of the Arp2/3 complex. Here, we show that heat shock …

Interactions of isolated C-terminal fragments of neural Wiskott-Aldrich syndrome protein (N-WASP) with actin and Arp2/3 complex

JF Gaucher, C Maugé, D Didry, B Guichard… - Journal of Biological …, 2012 - ASBMB
Wiskott-Aldrich syndrome proteins (WASP) are a family of proteins that all catalyze actin
filament branching with the Arp2/3 complex in a variety of actin-based motile processes. The …

Dyrk1A negatively regulates the actin cytoskeleton through threonine phosphorylation of N-WASP

J Park, JY Sung, J Park, WJ Song… - Journal of cell …, 2012 - journals.biologists.com
Neural Wiskott–Aldrich syndrome protein (N-WASP) is involved in tight regulation of actin
polymerization and dynamics. N-WASP activity is regulated by intramolecular interaction …

N-wasp and the arp2/3 complex are critical regulators of actin in the development of dendritic spines and synapses

AM Wegner, CA Nebhan, L Hu, D Majumdar… - Journal of Biological …, 2008 - ASBMB
Changes in the number, size, and shape of dendritic spines are associated with synaptic
plasticity, which underlies cognitive functions such as learning and memory. This plasticity is …